PMID: 6162038Mar 20, 1981Paper

Arterial chemoembolization with microencapsulated anticancer drug. An approach to selective cancer chemotherapy with sustained effects

JAMA : the Journal of the American Medical Association
T KatoM Harada

Abstract

Selective intra-arterial infusion of ethylcellulose microcapsules containing mitomycin exerts its therapeutic effects through infarction and sustained drug action--ie, chemoembolization. Sixty primary or secondary carcinomas in the kidney, liver, urinary bladder, prostate, cervix, vagina, sigmoid colon, Douglas' pouch, and bone were treated with single or repeated chemoembolizations using microcapsules delivered through percutaneous catheterization as a preoperative or palliative measure. Substantial tumor reduction of greater than 30% in measurable maximum diameter was found in 65% of the tumors, pain relief occurred in 80% and hemostasis in 100%. Preoperative chemoembolization remarkably facilitated radical surgery in 18 (82%) of 22 patients. The summed response rate was 77%. Systemic toxic effects were mild, and all patients tolerated the treatment. Though the follow-up periods are less than two years, 37 patients are alive with or without tumor.

Citations

Mar 15, 2001·Critical Reviews in Oncology/hematology·H H Sedlacek
Feb 1, 1991·Journal of Neuro-oncology·T Tomita
Sep 22, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·T NomuraM Hashida
Jun 1, 1990·Cardiovascular and Interventional Radiology·R YamadaM Satoh
Jul 1, 1985·Journal of Microencapsulation·J OkadaS Ueda
Jul 1, 1986·Journal of Microencapsulation·D C TsaiJ K Ma
Jul 1, 1988·Journal of Microencapsulation·A SawayaS Benita
Sep 1, 1994·Journal of Microencapsulation·C ZinuttiP Maincent
Jan 1, 1984·Journal of Microencapsulation·P MadouleA Roche
Apr 11, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Karim M EltawilMichele Molinari
Feb 11, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Karim M EltawilMichele Molinari
May 1, 1988·European Journal of Cancer & Clinical Oncology·C P Delcour, J L Struyven
Jan 18, 2006·European Journal of Radiology·B RadeleffG M Richter
Sep 1, 1999·European Journal of Clinical Investigation·H J BloemendalE E Voest
Nov 1, 1984·Current Problems in Cancer·S WallaceC Gianturco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.