Abstract
The Monro-Kellie hypothesis (MKH) states that volume changes in any intracranial component (blood, brain tissue, cerebrospinal fluid) should be counterbalanced by a co-occurring opposite change to maintain intracranial pressure within the fixed volume of the cranium. In this feasibility study, we investigate the MKH application to structural magnetic resonance imaging (MRI) in observing compensating intracranial volume changes during hypercapnia, which causes an increase in cerebral blood volume. Seven healthy subjects aged from 24 to 64 years (median 32), 4 males and 3 females, underwent a 3-T three-dimensional T1-weighted MRI under normocapnia and under hypercapnia. Intracranial tissue volumes were computed. According to the MKH, the significant increase in measured brain parenchymal volume (median 6.0 mL; interquartile range 4.5, 8.5; p = 0.016) during hypercapnia co-occurred with a decrease in intracranial cerebrospinal fluid (median -10.0 mL; interquartile range -13.5, -6.5; p = 0.034). These results convey several implications: (i) blood volume changes either caused by disorders, anaesthesia, or medication can affect outcome of brain volumetric studies; (ii) besides probing tissue displacement, this approach may assess th...Continue Reading
References
Mar 1, 1955·Annals of Surgery·R G ELLISONW F HAMILTON
Aug 31, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hanzhang LuPeter C M van Zijl
Feb 25, 2006·Stroke; a Journal of Cerebral Circulation·Mauro SilvestriniFabrizio Vernieri
Apr 21, 2007·The Journal of Physiology·Marat SlessarevJoseph A Fisher
Aug 29, 2007·Sports Medicine·Jordan S Querido, A William Sheel
Feb 9, 2008·Magma·P J WrightP A Gowland
Jan 10, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S K PiechnikP Jezzard
Mar 3, 2009·Magnetic Resonance Imaging·John Ashburner
Aug 13, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew F Glasser, David C Van Essen
Dec 16, 2011·Journal of Magnetic Resonance Imaging : JMRI·Anders WåhlinAnders Eklund
Apr 14, 2012·Journal of Biomedicine & Biotechnology·Cosimo Marcello Bruno, Maria Valenti
Oct 6, 2012·NeuroImage·Nicholas A BockStefan Geyer
Oct 11, 2012·Frontiers in Physiology·Seonghun YoonRobert M Rapoport
Jul 19, 2013·NeuroImage·T AlderliestenE T Petersen
Jan 8, 2014·The Journal of Physiology·Christopher K WilliePhilip N Ainslie
Apr 9, 2014·BMC Nephrology·Wei Chen, Matthew K Abramowitz
Sep 6, 2014·Journal of Applied Physiology·Jasper VerbreeMatthias J P van Osch
Nov 18, 2014·Anesthesiology·Lingzhong Meng, Adrian W Gelb
May 30, 2015·Journal of Neurosurgery·Shiong Wen LowVijay K Sharma
Jan 14, 2016·Computational Intelligence and Neuroscience·Adriënne M MendrikMax A Viergever
Feb 6, 2017·NeuroImage·C L TardifC J Gauthier
Apr 11, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patricia ClementEric Achten
Apr 20, 2018·PloS One·Lisa A van der KleijJill B De Vis