Arterial compliance influences the measurement of flow-mediated vasodilation, but not acetylcholine-mediated forearm blood flow. The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study

Atherosclerosis
Lars Lind

Abstract

Flow-mediated vasodilation (FMD) is low even in healthy elderly and therefore relations between FMD and cardiovascular risk factors might be hard to evaluate in the elderly. Using data from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, we investigated if a reduced arterial distensibility could influence FMD measurements. In the population-based PIVUS study (1016 subjects aged 70), assessments of arterial distensibility by ultrasound in the carotid artery (CCA) and FMD were performed. Endothelium-dependent vasodilation was also evaluated with the invasive forearm technique with acetylcholine (EDV) and by pulse wave analysis following terbutaline injection. A poor CCA distensibility was defined as <25th percentile in the healthy part of the population (n=131). FMD was significantly related to the Framingham risk score only in those with a good CCA distensibility (r=-0.16, p=0.0081 versus r=-0.06, p=0.17 in those with a poor CCA distensibility, p=0.0001 for difference). In contrast, the relationship between EDV and coronary risk was not affected by CCA distensibility (r=-0.11, p=0.018 versus r=-0.13, p=0.027). A reduced CCA distensibility could in part explain the low FMD values in the elderly. FMD cor...Continue Reading

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Oct 2, 2004·American Heart Journal·Laura R LoehrDavid M Herrington
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Citations

Oct 19, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Dick H J ThijssenDaniel J Green
Jun 23, 2009·American Journal of Respiratory and Critical Care Medicine·John D MaclayWilliam Macnee
Jun 22, 2013·Psychosomatic Medicine·Ashley N StillmanWilliam G Haynes
Oct 20, 2018·Journal of Hypertension·Lars LindErik Ingelsson
Apr 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Stefan GustafssonErik Ingelsson

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