PMID: 3320564Jan 1, 1987

Arterial effects of aldosterone and antimineralocorticoid compounds mechanism of action

Journal of Steroid Biochemistry
M Worcel, A M Moura

Abstract

The aim of our work was to study the mechanism of action of aldosterone and antialdosterone compounds on Na+ and K+ fluxes in vascular smooth muscle. In the long term, regulation of salt metabolism depends on aldosterone effects on Na+, K+, H+ and H2O transport by the renal tubules. Furthermore, it has been shown that aldosterone modifies several epithelial transports, inducing a positive sodium balance. The chronic in vivo administration of aldosterone modifies transmembrane ionic fluxes in vascular smooth muscle. Garwitz and Jones suggested that aldosterone may enhance net Na+ transport through the stimulation of the sodium pump. The results obtained in our laboratory indicate that aldosterone has a direct stimulatory action on ouabain-dependent and on ouabain-independent Na efflux. Furthermore, the mineralocorticoid enhances passive K permeability, as well as the Na pump dependent K influx. Both effects are blocked by antimineralocorticoid compounds. Recent experiments have shown that vasopressin potentiates some of the in vivo effects of aldosterone.

References

Jan 1, 1986·Journal of Steroid Biochemistry·A M MouraM Worcel
Nov 1, 1972·The American Journal of Medicine·D FeldmanI S Edelman
Jan 1, 1980·Journal of Steroid Biochemistry·M Moguilewsky, J P Raynaud

Citations

Jan 1, 1996·Pharmacology & Therapeutics·M K Agarwai
Feb 9, 2000·Pharmacology & Therapeutics·M K Agarwal, M Mirshahi
Feb 24, 2001·Journal of the American College of Cardiology·P LacolleyA Benetos
Oct 26, 1989·The New England Journal of Medicine·J H PrattN S Fineberg
Apr 2, 2003·Hypertension·Gengru JiangW Charles O'Neill
Mar 1, 1992·Hypertension·W WangI H Zucker
Jun 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·A BenetosM E Safar

Related Concepts

Aldosterone, (11 beta,17 alpha)-Isomer
Mineralocorticoid Receptor Antagonists
Drug Interactions
Muscle, Smooth, Vascular
Potassium
Rats, Brattleboro
August Rats
Rubidium Radioisotopes
Sodium
Pitressin

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