PMID: 11923626Mar 30, 2002Paper

Arterial ischemic stroke in childhood: the role of plasma-phase risk factors

Current Opinion in Neurology
Eirini NestoridiEric F Grabowski

Abstract

The role of plasma-phase risk factors for stroke in the pediatric age group is presently unclear due to the lack of sufficiently large prospective studies, and due to the fact that these risk factors do not apply uniformly to newborns, children with sickle cell disease, and older children. Available evidence indicates that factor V Leiden, prothrombin 20210A, and lipoprotein (a) are all important in the pathogenesis of arterial ischemic stroke in older children, but the role of other plasma-phase risk factors remains uncertain. The contribution of these risk factors to newborn stroke and the stroke of children with sickle cell disease is similarly unclear, likely because the ischemia in affected children is predominantly due to nonhematologic perinatal events and erythrocyte adhesion to endothelium with obstruction of flow in the cerebral microcirculation, respectively. Evaluation of childhood stroke should, in our view, always be performed from the standpoint of the presenting clinical symptoms, diagnostic imaging, and determination of plasma-phase risk factors. Therapeutic anticoagulation and use of antiplatelet agents at present focus on the older child.

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Citations

Mar 15, 2006·The Neurologist·Lori C Jordan
May 28, 2011·Journal of Child Neurology·Heather J FullertonGabrielle A Deveber
Jul 22, 2011·Stroke Research and Treatment·Sara CicconeCaterina Borgna-Pignatti
Jan 15, 2011·Stroke Research and Treatment·A YılmazG Deda
Jan 11, 2012·Indian Journal of Pediatrics·Parikshit SinghR K Singh
Nov 28, 2014·The International Journal of Neuroscience·Ilona KopytaBeata Sarecka-Hujar
May 4, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Marta Lopez-VicenteMichel T Torbey
Dec 4, 2015·Italian Journal of Pediatrics·Margherita RosaLuigi Titomanlio
Dec 20, 2005·Neuroimaging Clinics of North America·Brad R Brobeck, P Ellen Grant
Jan 18, 2012·European Journal of Clinical Investigation·Marisol Mirabelli-BadenierFabrizio Montecucco
Jan 19, 2012·Emergency Medicine International·Daniel S Tsze, Jonathan H Valente
Sep 29, 2006·Journal of Child Neurology·Eleni A VagiakouSotiria Mastroyianni
May 25, 2004·Anesthesia and Analgesia·Brian S Donahue

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