PMID: 8596152Nov 1, 1995Paper

Arterial lesions in Behçet's disease. A study in 25 patients

The Journal of Rheumatology
D u Lê Thi HuongP Godeau

Abstract

To identify the prognostic indicators of patients with Behçet's disease complicated with arterial lesions. Retrospective chart analysis of 25 consecutive patients with Behçet's disease and angiographically proven arterial lesions. Occlusive lesions were present in 7 patients, aneurysms in 3, and both occlusive and aneurysmal lesions in 15. High dose corticosteroids were not effective in isolated occlusive lesions and probably contributed to one fatal infection. Death was related to aneurysms in 5 patients. Twenty-seven vascular surgical procedures were performed in 15 patients. Arterial lesions recurred in all patients who did not received postoperative corticosteroids. Within a 2 yr period after operation, the rate of therapy failure was lower in the group of patients treated with a postoperative combination of corticosteroids and immunosuppressive drugs, compared to the group treated with corticosteroids alone. In patients treated for lower limb arterial lesions, the rate of relapse was similar whether venous autologous or prosthetic grafts were used. Graft thrombosis occurred in 3/7 patients given anticoagulants and in 3/4 patients with no antiaggregant or anticoagulant therapy. Aneurysms have a worse prognosis than occlusiv...Continue Reading

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