PMID: 9558193Apr 29, 1998Paper

Arterial obliteration in POEMS syndrome: possible role of vascular endothelial growth factor

The Journal of Rheumatology
M SoubrierB Sauvezie

Abstract

Acute arterial obliteration is a newly acknowledged manifestation of the POEMS syndrome (plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes), in which overproduction of proinflammatory cytokines has been implicated. We describe a case in which serum levels of proinflammatory cytokines were normal or slightly raised. In contrast, vascular endothelial growth factor (VEGF) was greatly increased. This angiogenic and vascular permeability factor is involved in the development of atheromatous and thrombotic lesions and may be responsible for the arterial complications of the disorder.

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Related Papers

The British Journal of Dermatology
O IshikawaH Ishikawa
Revista de neurologia
Carlos R Méndez-Herrera, Damisela Cordoví-Rodríguez
Mayo Clinic Proceedings
Gunjan Y GandhiMichael D Brennan
© 2022 Meta ULC. All rights reserved