PMID: 9003396Jan 1, 1997Paper

Arterial oxygen partial pressures reduce the insulin-dependent induction of the perivenously located glucokinase in rat hepatocyte cultures: mimicry of arterial oxygen pressures by H2O2

The Biochemical Journal
T KietzmannK Jungermann

Abstract

Liver glucokinase (GK) is localized predominantly in the perivenous zone. GK mRNA was induced by insulin maximally under venous O2 partial pressure (pO2) and only half-maximally under arterial pO2. CoCl2 and desferrioxamine mimicked venous pO2 and enhanced the insulin-dependent induction of GK mRNA under arterial pO2. H2O2 mimicked arterial pO2 and reduced insulin-induced GK mRNA under venous pO2 to the lower arterial levels. Thus the zonal O2 gradient in liver seems to have a key role in the heterogenous expression of the GK gene.

Citations

Dec 3, 2014·Biochemical and Biophysical Research Communications·Asako SatoKosuke Tsukada
Mar 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Qing LiuThomas Kietzmann
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Jungermann, T Kietzmann
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V M ChristoffelsW H Lamers
Aug 30, 2008·Cellular and Molecular Life Sciences : CMLS·P B Iynedjian
Sep 11, 2009·The Journal of Biological Chemistry·Goutham Kumar GanjamThomas Kietzmann
Aug 25, 2017·Journal of the Royal Society, Interface·Jana SchleicherStefan Schuster
Oct 25, 2011·Journal of Cellular Biochemistry·Romina BertinatAlejandro J Yáñez
Feb 1, 2011·IUBMB Life·María L MassaFlavio Francini
Sep 26, 2000·Molecular Genetics and Metabolism·C T D'Angio, J N Finkelstein
May 21, 2005·Seminars in Cell & Developmental Biology·Thomas Kietzmann, Agnes Görlach
Mar 21, 2007·Archives of Biochemistry and Biophysics·Jacek LenartThomas Kietzmann

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