Apr 16, 2016

Arterial pressure, end-tidal carbon dioxide, and central venous oxygen saturation in reflecting compression depth

Acta Anaesthesiologica Scandinavica
S-J RyuK-W Jeung


We sought to investigate the utility of arterial pressure, end-tidal carbon dioxide (ETCO2 ), and central venous oxygen saturation (SCVO2 ) to guide compression depth adjustment. Thus, in a pig model of cardiac arrest, we observed these parameters during cardiopulmonary resuscitation (CPR) with optimal and suboptimal compression depths. Sixteen pigs underwent three experimental sessions after induction of ventricular fibrillation. First, the animals received two 4-min CPR trials with either optimal (20% of the anteroposterior diameter) or suboptimal (70% of the optimal depth) compression depth. Second, the animals received two 5-min CPR trials with optimal compression depth, in which adrenaline (0.02 mg/kg) or saline placebo was administered. Third, the animals randomly received compression with either optimal or suboptimal depth during advanced cardiovascular life support. The systolic arterial pressure reflected compression depth most accurately and immediately (area under the curve [AUC], 0.895-0.939 without adrenaline and 0.928-1.000 with adrenaline). Although the response of ETCO2 to the change in compression depth was 0.5 min slower than that of the systolic arterial pressure, the performance of ETCO2 was comparable with ...Continue Reading

  • References33
  • Citations5


  • References33
  • Citations5


Mentioned in this Paper

Arterial Pulse Pressure
Ventricular Fibrillation
Diastolic Blood Pressure
Basic Cardiac Life Support
Administration Procedure
Mean Aortic Pressure
Cardiopulmonary Resuscitation
Venous Oxygen Saturation Measurement
Epinephrine Measurement

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