PMID: 9180100Jun 1, 1997Paper

Arterial reactivity is enhanced in genetic males taking high dose estrogens

Journal of the American College of Cardiology
J A McCrohonD S Celermajer

Abstract

We sought to assess whether high dose estrogen treatment is associated with enhanced arterial reactivity in genetic males. Although estrogens have been shown to enhance arterial reactivity in women, and are thereby thought to confer cardiovascular benefit, the vascular effects of long-term estrogen therapy in genetic males is unknown. We studied the arterial physiology of 30 genetic males--15 male to female transsexuals receiving long-term high dose estrogen therapy and 15 healthy male control subjects matched for age, smoking history and vessel size. Using external vascular ultrasound, brachial artery diameter was measured at rest, after flow increase (causing endothelium-dependent dilation [EDD]) and after nitroglycerin (GTN), an endothelium-independent dilator. Blood pressure, cholesterol and testosterone levels were also measured in each subject. Total testosterone and free testosterone index levels were lower in the transsexuals compared with the control subjects (p < 0.001). In contrast, EDD was significantly higher in the transsexuals than in the control males (mean [+/-SD] 7.1 +/- 3.1% vs. 3.2 +/- 2.8%, p = 0.001), as was the GTN response (21.2 +/- 6.7% vs. 14.6 +/- 3.3%, p = 0.002). Total and high density lipoprotein c...Continue Reading

References

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T HayashiG Chaudhuri
Oct 1, 1991·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T L Bush
Dec 1, 1991·British Journal of Pharmacology·C W JiangP Collins
Jan 1, 1990·Annals of the New York Academy of Sciences·F M Sacks, B W Walsh
Oct 23, 1986·The New England Journal of Medicine·P L LudmerP Ganz
Feb 1, 1983·American Journal of Epidemiology·D L WingardE Barrett-Connor
Sep 25, 1995·Biochemical and Biophysical Research Communications·T HayashiA Iguchi
Nov 1, 1995·Journal of the American College of Cardiology·T J AndersonA C Yeung
Dec 15, 1994·Annals of Internal Medicine·E H LiebermanM A Creager
Aug 1, 1994·Journal of the American College of Cardiology·D S CelermajerJ E Deanfield
Aug 1, 1994·Circulation·D M GilliganR O Cannon
May 1, 1994·Circulation·R H KarasM E Mendelsohn
Oct 1, 1993·The Journal of Clinical Endocrinology and Metabolism·M T SubbiahZ Rymaszewski
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·S M HermanD S Celermajer

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Citations

Dec 4, 2003·Current Opinion in Pharmacology·Yasmine Sayed, Pamela Taxel
Jun 19, 2001·Molecular and Cellular Endocrinology·G LombardiM De Rosa
Oct 17, 2002·Vascular Pharmacology·Richard E White
Nov 3, 2001·Journal of the American College of Cardiology·K K KohE K Shin
Nov 11, 1998·Journal of the American College of Cardiology·R J McCredieD S Celermajer
Feb 24, 2001·Clinical Endocrinology·M A SaderD S Celermajer
Jun 11, 1999·The New England Journal of Medicine·M E Mendelsohn, R H Karas
Jun 29, 2000·Current Opinion in Obstetrics & Gynecology·T Simoncini, A R Genazzani
Nov 1, 2005·Expert Opinion on Investigational Drugs·Dirk C Felmeden, Gregory Y H Lip
Dec 15, 2015·Experimental Physiology·Daniel J GreenBu B Yeap
Jun 17, 2003·Clinical Endocrinology·Mark A SaderDavid S Celermajer
Sep 2, 2005·European Journal of Pharmacology·Rika EgamiHitoo Nakano
Feb 7, 2006·Journal of the American College of Cardiology·Carl J PepineC Noel Bairey Merz
Jan 22, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Neja MudrovcicKarolina Kublickiene
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Pawan D Patel, Rohit R Arora
Sep 2, 2006·Circulation Research·Carl J PepineDaniel F Pauly
Dec 13, 2003·Circulation Research·Michael E Mendelsohn, Giuseppe M C Rosano
Nov 1, 2003·Circulation Research·Robert LewKrishnankutty Sudhir
Nov 26, 1999·Circulation Research·M García-DuránA López-Farré
Mar 12, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·I C WestendorpJ C Witteman
Apr 18, 2003·Endocrine Reviews·Fredrick C W Wu, Arnold von Eckardstein
Jun 6, 2003·Endocrine Reviews·Peter Y LiuDavid J Handelsman
Oct 10, 2002·Endocrine Reviews·Ken L Chambliss, Philip W Shaul
Nov 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Michael ZitzmannEberhard Nieschlag
Aug 15, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Vin TangprichaStuart R Chipkin
Dec 13, 2003·Journal of Endocrinological Investigation·M Zitzmann, E Nieschlag
May 26, 2006·Clinical Science·Christopher J MalkinKevin S Channer
Feb 5, 2000·Journal of Applied Physiology·M R RinderA A Ehsani
Aug 22, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J R RouleauJ G Kingma
Jun 25, 1998·The American Journal of Physiology·A A Nekooeian, C C Pang

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