Arterial remodeling at the reference site after angioplasty in the atherosclerotic rabbit model

Arteriosclerosis, Thrombosis, and Vascular Biology
T KakutaD P Faxon

Abstract

Recent studies suggest that arterial remodeling plays an important role in restenosis and that remodeling at the reference site may also occur. To assess the chronic effect of the reference site remodeling on angioplasty results, we evaluated reference site remodeling in an experimental atherosclerotic restenosis model. Histological sections of iliac stenoses and their associated proximal reference segments from 50 atherosclerotic rabbits killed 4 weeks after angioplasty were analyzed. Lumen area (LA), external elastic lamina area (EEL), and intimal plus medial areas (I+M) were measured at the lesion (L) and reference (R) sites. Angiography was performed preangioplasty, immediately postangioplasty, and 4 weeks postangioplasty. Restenosis was defined as an angiographic loss/gain ratio of greater than 50% at follow-up angiography. Twenty-three lesions were restenotic (R+) and 32 were not (R-). There was no difference in reference site diameters (RD) between these two groups at the time of angioplasty. However, RDs were significantly smaller in the R+ group than in the R- group (1.24+/-0.18 versus 1.52+/-0.28 mm, n=55, P<.01) at 4-week follow-up. Morphometric analysis also showed a smaller LA(R) in the R+ group (0.85+/-0.27 versus...Continue Reading

References

May 1, 1991·Journal of the American College of Cardiology·J W CurrierD P Faxon
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Mar 1, 1982·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D P FaxonT J Ryan

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Citations

Jun 4, 2004·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Pierre-André Doriot, Pierre-André Dorsaz
Mar 2, 2006·Toxicologic Pathology·Arturo G Touchard, Robert S Schwartz

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