Arterial remodeling in response to hypertension using a constituent-based model

American Journal of Physiology. Heart and Circulatory Physiology
Alkiviadis Tsamis, N Stergiopulos

Abstract

Hypertension-induced arterial remodeling has been previously modeled using stress-driven remodeling rate equations in terms of global geometrical adaptation (Rachev A, Stergiopulos N, Meister JJ. Theoretical study of dynamics of arterial wall remodeling in response to changes in blood pressure. J Biomech 29: 635-642, 1996) and was extended later to include adaptation of material properties (Rachev A, Stergiopulos N, Meister JJ. A model for geometric and mechanical adaptation of arteries to sustained hypertension. J Biomech Eng 120: 9-17, 1998). These models, however, used a phenomenological strain energy function (SEF), the parameters of which do not bear a clear physiological meaning. Here, we extend the work of Rachev et al. (1998) by applying similar remodeling rate equations to a constituent-based SEF. The new SEF includes a statistical description for collagen engagement, and remodeling now affects material properties only through changes in the collagen engagement probability density function. The model predicts asymptotic wall thickening and unchanged deformed inner radius as to conserve hoop stress and intimal shear stress, respectively, at the final adapted hypertensive state. Mechanical adaptation serves to restore ar...Continue Reading

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Citations

Nov 28, 2009·Biomechanics and Modeling in Mechanobiology·H SchmidM Itskov
May 18, 2010·Biomechanics and Modeling in Mechanobiology·Alexander Rachev, Rudolph L Gleason
May 16, 2012·Biomechanics and Modeling in Mechanobiology·Jeffrey K Cheng, Jessica E Wagenseil
May 21, 2010·Mathematical Medicine and Biology : a Journal of the IMA·L CardamoneJ D Humphrey
Jul 24, 2008·Journal of the Royal Society, Interface·A ValentínJ D Humphrey
Mar 29, 2013·Journal of the Royal Society, Interface·Alkiviadis TsamisDavid A Vorp
Aug 7, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·A Valentín, J D Humphrey
Oct 17, 2009·Journal of Biomechanical Engineering·Alkiviadis TsamisAlexander Rachev
Feb 10, 2011·Journal of Biomechanical Engineering·Yaniv HollanderYoram Lanir
Jul 1, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Jacques OhayonRoderic I Pettigrew
Mar 29, 2014·Biomechanics and Modeling in Mechanobiology·Alkiviadis TsamisDavid A Vorp
Dec 14, 2011·Computer Methods in Biomechanics and Biomedical Engineering·H SchmidM Itskov
Apr 28, 2009·Journal of Biomechanics·Paul N WattonGerhard A Holzapfel
Feb 3, 2009·Journal of Biomechanics·Alkiviadis Tsamis, Nikos Stergiopulos
Dec 4, 2014·Annals of Biomedical Engineering·Jungsil Kim, Jessica E Wagenseil
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Nov 20, 2012·Circulation·Victor AboyansUNKNOWN Council on Cardiovascular Radiology and Intervention, and Council on Cardiovascular Surgery and Anesthesia
Jul 1, 2014·Journal of Biomechanical Engineering·Shijia Zhao, Linxia Gu
May 29, 2010·Physics in Medicine and Biology·Simone BaloccoChristian Cachard
Jul 5, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Alkiviadis TsamisNikos Stergiopulos
Dec 30, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Bart SpronckKoen D Reesink
Nov 14, 2020·Fluids and Barriers of the CNS·Gabryel Conley NatividadBryn A Martin
Apr 10, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Yasmeen M FarraChiara Bellini

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