Arterial spin labelling shows functional depression of non-lesion tissue in chronic Wernicke's aphasia

Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Holly RobsonRoland Zahn

Abstract

Behavioural impairment post-stroke is a consequence of structural damage and altered functional network dynamics. Hypoperfusion of intact neural tissue is frequently observed in acute stroke, indicating reduced functional capacity of regions outside the lesion. However, cerebral blood flow (CBF) is rarely investigated in chronic stroke. This study investigated CBF in individuals with chronic Wernicke's aphasia (WA) and examined the relationship between lesion, CBF and neuropsychological impairment. Arterial spin labelling CBF imaging and structural MRIs were collected in 12 individuals with chronic WA and 13 age-matched control participants. Joint independent component analysis (jICA) investigated the relationship between structural lesion and hypoperfusion. Partial correlations explored the relationship between lesion, hypoperfusion and language measures. Joint ICA revealed significant differences between the control and WA groups reflecting a large area of structural lesion in the left posterior hemisphere and an associated area of hypoperfusion extending into grey matter surrounding the lesion. Small regions of remote cortical hypoperfusion were observed, ipsilateral and contralateral to the lesion. Significant correlations ...Continue Reading

References

Mar 11, 2003·Physical Medicine and Rehabilitation Clinics of North America·Steven C Cramer
Oct 8, 2003·Cerebrovascular Diseases·Palle Møller PedersenTom Skyhøj Olsen

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Software Mentioned

INFOMAX
jICA
Matlab Fusion ICA Toolbox ( FIT
Matlab2013a
MarsBaR
SPM8
MRIcron

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