PMID: 8586823Sep 1, 1995Paper

Arterial spontaneous rhythmic contractile activity in humans and rats: spectral analysis and regulatory mechanisms

Journal of Hypertension
D RizzoniE Agabiti Rosei

Abstract

Many experimental observations have demonstrated the presence of spontaneous cyclic vasomotor activity (CVA) in large and small arteries. This study aimed to evaluate the characteristics of spontaneous CVA in rat and human resistance arteries, and to investigate its possible interference with the evaluation of sympathetic activity by means of spectral analysis of blood pressure in vivo. In study 1 we examined small mesenteric arteries of spontaneously hypertensive rats and Wistar-Kyoto rats, as well as small omental arteries of normotensive subjects and hypertensive patients (Mulvany and Halpern technique). CVA was enhanced by the agonists of nitric oxide release, and was abolished by the inhibitors of nitric oxide or cyclic GMP synthesis. A potassium channel, which is barium- and zinc-sensitive and tetraethylammonium-insensitive, seems to play a crucial role in the genesis of CVA. In rats and in humans the frequency of CVA fell exactly in the frequency band ('low frequencies') of power spectral analysis of blood pressure usually considered to be an 'index of sympathetic activity'. In study 2, a power spectral analysis of blood pressure variability before and after intra-arterial infusion of noradrenaline or acetylcholine was p...Continue Reading

Citations

Nov 2, 2004·European Journal of Applied Physiology·William H Cooke, Jason R Carter
Oct 24, 1998·Clinical and Experimental Pharmacology & Physiology·R LétienneC Barrès
Aug 16, 2002·The Journal of Physiology·Rong ZhangBenjamin D Levine
Jan 13, 2006·Journal of Pharmacological Sciences·Natasa StojnicHelmut Heinle
May 4, 1999·Clinical and Experimental Pharmacology & Physiology·K ShimamuraS Sunano
Sep 7, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Alberto RadaelliMarco Di Rienzo
Sep 14, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paola A Lanfranchi, Virend K Somers
Mar 7, 2000·Journal of Hypertension·A RadaelliA U Ferrari
Dec 23, 1999·Journal of Hypertension·J BlancB Jover
Nov 15, 1997·The American Journal of Physiology·B F SlangenL L Peeters
Sep 18, 2002·Journal of Applied Physiology·William H CookeBenjamin D Levine
Jul 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·P van de BorneV K Somers

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