Arterial Stiffness in Chronic Kidney Disease and End-Stage Renal Disease

Blood Purification
G London

Abstract

Accelerated ageing is observed in patients with chronic kidney disease (CKD)/end-stage renal disease. Premature vascular aging and arterial stiffening are the most characteristic features of this "progeria" that is already observed in those with the early stages of CKD. Aortic stiffening is associated with high characteristic impedance, left ventricular hypertrophy, decreased coronary perfusion, and is a strong prognostic marker of mortality and cardiovascular morbidity. With aging, the arterial stiffening is more pronounced in the aorta and central arteries than in peripheral conduit arteries. This leads to progressive decrease and inversion of the arterial stiffness gradient and systemic reflection coefficient, leading to less protection of the microcirculation in the event of high-pressure transmission towards it Arterial stiffening is multifactorial with systemic microinflammation being one of the most important associated factors primarily associated with vascular calcifications.

References

May 11, 1999·Circulation·J BlacherG M London
Jan 24, 2003·Diabetes·Eiji KimotoYoshiki Nishizawa
Mar 9, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ming-Cheng WangJeng-Jong Huang
Jan 13, 2006·Kidney International·M BrietP Boutouyrie
Sep 29, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sophia ZoungasBarry P McGrath
Oct 16, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gerard M London, Bruno Pannier
Jun 21, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mark J Sarnak, Robert N Foley
Apr 27, 2012·Kidney International·Marie BrietGérard M London
Oct 8, 2014·Nature Reviews. Nephrology·Jeroen P KoomanPeter Stenvinkel
Oct 18, 2015·Journal of the American Society of Nephrology : JASN·Gérard M LondonBruno Pannier
Nov 30, 2016·American Journal of Nephrology·João Pedro FerreiraGerard M London

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Citations

Feb 26, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Branko BraamAminu K Bello
Sep 7, 2018·Transplantation·Matthew TunbridgeAlan G Jardine
Jul 31, 2019·Current Opinion in Nephrology and Hypertension·Luke PickupCharles J Ferro
Mar 17, 2020·Journal of Atherosclerosis and Thrombosis·Pasquale EspositoGiacomo Garibotto
Mar 28, 2020·Journal of Clinical Medicine·Yi-Chou HouYuh-Feng Lin
Sep 3, 2020·Medicina·Marko PetrovicVisnja Lezaic
Jan 17, 2020·The Journal of Clinical Hypertension·Wenkai XiaoHongmei Wu
Dec 15, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Hsin-Yu YangBang-Gee Hsu
Feb 16, 2020·American Journal of Hypertension·Yi ZhangMichel E Safar
Oct 31, 2020·The Journal of Clinical Hypertension·Charalampos LoutradisPantelis Sarafidis
Jan 8, 2021·International Journal of Nephrology and Renovascular Disease·Hon-Chun HsuPatrick H Dessein
Feb 11, 2021·Clinical Kidney Journal·Jin Seon JeongSeung Seok Han
Mar 9, 2021·International Journal of Nephrology·Hon-Chun HsuPatrick H Dessein
Jan 26, 2021·Blood Pressure Monitoring·Agne Laucyte-CibulskieneAleksandras Laucevicius
Apr 30, 2021·Tzu Chi Medical Journal·Jen-Pi Tsai, Bang-Gee Hsu
May 21, 2021·Tissue Engineering and Regenerative Medicine·Panagiotis MallisMichalis Katsimpoulas
Jul 3, 2021·Jornal Vascular Brasileiro·Atakan Turgutkaya, Gülay Aşçı
Aug 3, 2021·Frontiers in Pharmacology·Qian DongQin Zhou

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