Arterial stiffness in dialysis patients: where are we now?

International Urology and Nephrology
Mehmet KanbayAdrian Covic

Abstract

Patients with end-stage renal disease treated by chronic dialysis have an impressive mortality, which more than half of this mortality is attributable to cardiovascular disease. Despite stratification for sex, race, and the presence of diabetes, cardiovascular disease mortality is 10-30 times higher in dialysis patients compared to general population. In dialysis patients, both atherosclerosis (mainly affecting the intima of the arteries) and arteriosclerosis (affecting predominantly the media of large- and middle-sized arteries diffusely) are highly prominent. Arteriosclerosis characterized by reduced arterial compliance (i.e., reduced elasticity of the arteries) is due to increased fibrosis, loss of elastic fibers, and extensive vessel wall calcification. Arteriosclerosis is closely related to arterial stiffness. A generally accepted mechanistic view is that an increase in arterial stiffness causes a premature return of reflected waves in late systole, increasing central pulse pressure, thus systolic. An increased arterial stiffness can increase the risk of stroke through several mechanisms, including an increase in central pulse pressure, influencing arterial remodeling both at the site of the extracranial and intracranial a...Continue Reading

References

Jan 1, 1990·Kidney International·G M LondonA M London
Feb 12, 1998·The Journal of Biological Chemistry·W Jahnen-DechentM Blessing
Apr 29, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·J BlacherG M London
Nov 20, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R N FoleyM J Sarnak
Dec 31, 1998·The New England Journal of Medicine·D S Celermajer
Jun 22, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A P GuérinF Metivier
May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·T ShimadaT Yamashita
Aug 24, 2001·Journal of the American Society of Nephrology : JASN·Angela Yee Moon WangJohn Elsby Sanderson
Dec 26, 2001·Journal of the American Society of Nephrology : JASN·J L Tycho VuurmansHein A Koomans
Feb 6, 2002·Circulation·Yin TintutLinda L Demer
May 23, 2002·American Journal of Hypertension·Luc M Van BortelChristian Thuillez
Oct 19, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gérard M LondonFabien Métivier
Aug 5, 2003·The Journal of Clinical Investigation·Cora SchaferWilli Jahnen-Dechent
Oct 29, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yao-Ping LinChen-Huan Chen
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Takashi ShimadaTakeyoshi Yamashita
Apr 17, 2004·Kidney International·Ali A HaydarDavid J A Goldsmith
Jun 24, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ali A HaydarDavid J A Goldsmith
Jan 4, 2005·Blood Purification·Sharon M Moe, Neal X Chen
Jan 28, 2005·Kidney International·Adrian CovicDavid J A Goldsmith
Apr 14, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lindsay J ChestertonChristopher W McIntyre
May 19, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Angela Yee-Moon WangJohn E Sanderson
Jun 16, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Adrian CovicDavid J A Goldsmith
Jul 15, 2005·Kidney International·Mario CozzolinoEduardo Slatopolsky
Sep 1, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Maurizio BossolaGiovanna Luciani
Sep 30, 2005·Hemodialysis International·Shuzo KobayashiTakayasu Ohtake
Oct 13, 2005·Hemodialysis International·Nicoleta-Genoveva MardareAdrian Covic
Nov 1, 2005·Journal of the American College of Cardiology·Carmel M McEnieryUNKNOWN ACCT Investigators
Jan 7, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marc M H HermansKarel M L Leunissen

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Citations

Feb 5, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kevin S HeffernanVandana Menon
Jan 31, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Adrian CovicFrancesco Locatelli
Apr 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Marek CzarkowskiStanislaw Niemczyk
Nov 19, 2013·International Urology and Nephrology·Fabrice Mac-WayMohsen Agharazii
Jul 30, 2011·Current Hypertension Reports·Tara I Chang
Dec 15, 2010·International Urology and Nephrology·Shigeru OtsuboKosaku Nitta
Mar 23, 2011·International Urology and Nephrology·Simona HogasAdrian Covic
Mar 23, 2012·International Urology and Nephrology·Mehmet KanbayAdrian Covic
Jul 4, 2012·International Urology and Nephrology·Tekin AkpolatKenan Ateş
Jul 15, 2015·European Journal of Clinical Investigation·Markus TölleMarkus van der Giet
Aug 8, 2015·International Urology and Nephrology·Zeynep BalHaldun Muderrisoglu
Feb 5, 2015·Hemodialysis International·Handan ÖğünçYavuz Yeniçerioğlu
Nov 20, 2012·Atherosclerosis·Mehmet Nuri TuranErcan Ok
May 18, 2010·Journal of the American Society of Hypertension : JASH·Simona M HogasAdrian Covic
Oct 26, 2013·Nephron. Clinical Practice·Adelina MihaescuAdalbert Schiller
Dec 21, 2018·The Journal of Clinical Hypertension·Aslihan YerlikayaMehmet Kanbay
Jul 19, 2013·The Korean Journal of Internal Medicine·Petar AvramovskiAleksandar Sikole
Jun 1, 2016·The Cochrane Database of Systematic Reviews·Sagar U NigwekarMeg J Jardine
Dec 24, 2016·The International Journal of Artificial Organs·Ibrahim GuneySamil Ecirli
Apr 29, 2019·Journal of Nephrology·Baris AfsarMehmet Kanbay
Jan 12, 2021·Hypertension·Mehmet KanbayAlberto Ortiz
Aug 28, 2021·Diagnostics·Mădălina Ioana MoisiMircea Ioachim Popescu

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