Arterial stiffness is associated with depression in middle-aged men - the Maastricht Study.

Journal of Psychiatry & Neuroscience : JPN
Veronica OneteMiranda T Schram

Abstract

Arterial stiffening may underlie the association between depression and cardiovascular disease (CVD), but reported data are inconsistent. We investigated the associations between aortic stiffness and major depressive disorder (MDD) and depressive symptoms, and whether these differed by sex and age. We measured carotid to femoral pulse wave velocity (cfPWV) using applanation tonometry, and we assessed depression using the Mini-International Neuropsychiatric Interview (MINI) and the Patient Health Questionnaire-9 (PHQ-9) in a cohort of participants from The Maastricht Study. Logistic and negative binominal models were adjusted for age, type 2 diabetes mellitus (T2DM), mean arterial pressure (MAP) and CVD risk factors. We included 2757 participants in our analyses (48.8% men, mean age 59.8 ± 8.1 yr, 27% T2DM). We found that cfPWV was associated with MDD in men (fully adjusted odds ratio [OR] 2.36, 95% confidence interval [CI] 1.45-3.84), but not in women (OR 1.57, 95% CI 0.93-2.66), aged 60 years or younger. The ORs were not significant in individuals older than 60 years (men: OR 1.03, 95% CI 0.63-1.68; women: OR 0.64, 95% CI 0.32-1.31). Similarly, cfPWV was associated with a higher PHQ-9 score in men (rate ratio 1.28, 95% CI 1.09...Continue Reading

Citations

Sep 27, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sun Jae JungHyeon Chang Kim
Nov 17, 2020·Complementary Therapies in Medicine·Alexander A PiñaStacy D Hunter
Aug 24, 2018·F1000Research·Thomas van Sloten, Miranda Schram
Nov 10, 2018·Biological Psychiatry·Thomas T van SlotenJean-Philippe Empana
Jul 7, 2021·Journal of Affective Disorders·Vincenza GianfrediMiranda T Schram
Aug 29, 2021·Heart, Lung & Circulation·Ute SeelandUNKNOWN Sex and Gender VascAgeNet Expert Group

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