Arterial Stiffness Is Associated With QTc Interval Prolongation in Patients With Heart Failure

Biological Research for Nursing
Salah Al-ZaitiFadi Khraim

Abstract

A prolonged corrected QT (QTc) interval is a known risk factor for adverse cardiac events. Understanding the determinants and physiologic correlates of QTc is necessary for selecting proper strategies to reduce the risk of adverse events in high-risk patients. We sought to evaluate the role of arterial stiffness in heart failure as a determinant of QTc prolongation. This was an observational study that recruited ambulatory heart failure patients (New York Heart Association Classes I-II) from an outpatient heart failure clinic. In the supine resting position, consented patients underwent noninvasive 12-lead electrocardiograph (ECG) and hemodynamic monitoring using BioZ Dx impedance cardiography. ECGs were evaluated by a reviewer blinded to clinical data, and QTc interval was automatically computed. Patients with pacing or bundle branch block (BBB) were analyzed separately. Strengths of associations were evaluated using Pearson's r coefficients and multivariate linear regression. The final sample ( N = 44) was 62 ± 13 years of age and 64% male with ejection fraction of 34% ± 12%. At univariate level, QTc interval moderately ( r > .50) correlated with cardiac output, left cardiac work index, systemic vascular resistance, and total...Continue Reading

References

Oct 1, 1980·Annals of Internal Medicine·W M Smith, J J Gallagher
Mar 12, 1999·Journal of Molecular and Cellular Cardiology·C M Boulanger
Apr 6, 1999·Nursing Research·J McFetridge, A Sherwood
Jul 6, 2000·British Journal of Pharmacology·A S De VrieseP M Vanhoutte
Nov 14, 2000·Circulation Research·H Cai, D G Harrison
Apr 24, 2003·JAMA : the Journal of the American Medical Association·Sana M Al-KhatibRobert M Califf
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Berit T JensenJørgen K Kanters
Aug 5, 2005·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Stephen R BenoitDavid J Graham
Jan 18, 2006·Journal of the American College of Cardiology·Sabine M J M StrausJacqueline C M Witteman
Jan 24, 2007·Journal of the American College of Cardiology·Ian TopilskiSami Viskin
Mar 28, 2008·Journal of Electrocardiology·Syed Mohammad Afzal SohaibPeter H Whincup
Oct 30, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Daisuke MaebuchiYutaka Kiyohara
Mar 3, 2009·American Heart Journal·W H Wilson Tang, Wilson Tong
Mar 3, 2009·Heart Failure Clinics·Melike Bayram, Clyde W Yancy
Jul 28, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Kimmo PorthanLasse Oikarinen
Jul 21, 2010·British Journal of Clinical Pharmacology·Charlotte van NoordBruno H Ch Stricker
Feb 4, 2011·Nutrition Journal·Silvio BuscemiSalvatore Verga
Sep 3, 2013·Journal of Electrocardiology·Salah S Al-ZaitiMary G Carey
Dec 3, 2014·Journal of Electrocardiology·Ioana Mozos
Sep 5, 2015·Journal of Occupational and Environmental Medicine·Salah Al-ZaitiDavid Hostler

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

excel
SPSS

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.