Arterial thrombin activity after angioplasty in an atherosclerotic rabbit model: time course and effect of hirudin

Circulation
W L BarryI J Sarembock

Abstract

A 2-hour infusion of the direct thrombin inhibitor hirudin at the time of balloon angioplasty limits restenosis in the focally atherosclerotic rabbit. Although short-term administration of hirudin may have a prolonged biological effect, the effect of hirudin on vessel thrombin activity has not been previously studied in an animal model of angioplasty. We hypothesized that a short intravenous infusion of hirudin would result in prolonged inhibition of arterial wall-associated thrombin activity (ATA) after angioplasty. Sixty-one rabbits received recombinant hirudin (r-hirudin)(1 mg/kg bolus plus 1 mg x kg(-1) x h(-1)x2hours) or bolus heparin (controls, 150 U/kg) intravenously at the time of femoral balloon angioplasty. ATA was measured through exposure of arterial segments ex vivo to fibrinogen and conducting an assay for fibrinopeptide A (FPA). ATA was low in nonballooned, atherosclerotic vessels (FPA=0.5+/-0.3 ng x mL(-1) x mg(-1)) but increased significantly at 24 hours after angioplasty in the heparin group (3.7+/-0.9 ng x mL(-1) x mg(-1), P<.01 versus baseline, n=9) but not in the hirudin group (FPA = 1.4+/-0.3; P=NS versus baseline, P<.02 versus heparin controls, n=8). The time course of ATA after angioplasty was assessed i...Continue Reading

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Citations

Sep 2, 1998·The American Journal of Cardiology·J E BurchenalJ A Bittl
Aug 26, 1998·Progress in Cardiovascular Diseases·W B BatchelorB H Strauss
Nov 14, 1997·Journal of the American College of Cardiology·Y BirnbaumR J Siegel
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Oct 1, 2018·Journal of Cellular Biochemistry·Najmeh JaberiSeyed Mahdi Hassanian
Apr 13, 2000·International Journal of Experimental Pathology·G A Ferns, T Y Avades

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