PMID: 11909890Mar 23, 2002Paper

Arterial wall production of cytokines in giant cell arteritis: results of a pilot study using human temporal artery cultures

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Hubert BlainClaude Jeandel

Abstract

Giant cell arteritis (GCA) is a subacute periarteritis predominantly affecting segments of the external carotids of elderly patients. Vasculitic lesions in GCA samples might be characterized by in situ production of cytokines mRNA, indicative of macrophage and T-cell activation. However, whether the cytokine production of vessels with arteritis differs from that of vessels exposed to inflammatory conditions that originate peripheral to the vessel remains unknown. We investigated cytokine and soluble receptor cytokine production in blood samples and cultures of human temporal arteries from 22 consecutive patients (mean age 77 +/- 6 years) further investigated for possible diagnosis of GCA: 7 patients had GCA and 15 had neither GCA nor vasculitis but had other inflammatory, infectious, or malignant diseases (controls). The production of cytokines and soluble cytokine receptors in the supernatants of cultures of 3-mm segments of temporal artery specimens, before and after lipopolysaccharide (LPS) stimulation (10 ng/ml and 10 microg/ml) and in serum, was quantified using sandwich enzyme-linked immunosorbent assay (ELISA). Cytokine production by temporal arteries increased significantly and in a dose-dependent manner (p <.01) after ...Continue Reading

References

Jun 1, 1991·Journal of Clinical Pathology·S O WawrykJ Rode
Oct 1, 1983·Arthritis and Rheumatism·P M BanksG G Hunder
Oct 1, 1994·Annals of Internal Medicine·C M WeyandJ J Goronzy
Jan 1, 1997·Arthritis and Rheumatism·C M WeyandJ J Goronzy
Sep 18, 1998·Drugs·P Libby, M Aikawa
Feb 20, 1999·Arthritis and Rheumatism·A BrackC M Weyand
Oct 26, 1999·Circulation Research
Mar 29, 2000·Biochemical and Biophysical Research Communications·M ImaiS C Robson
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·E N BakkerE VanBavel
May 19, 2000·Arthritis and Rheumatism·C M WeyandJ J Goronzy

❮ Previous
Next ❯

Citations

Jul 11, 2003·The New England Journal of Medicine·Cornelia M Weyand, Jörg J Goronzy
Apr 15, 2003·The Journal of Dermatology·Midori MatsushimaHitoshi Mizutani
Apr 29, 2005·Best Practice & Research. Clinical Rheumatology·Nicolò PipitoneCarlo Salvarani
Feb 24, 2015·Seminars in Arthritis and Rheumatism·Javier LoriceraMiguel Á González-Gay
Feb 8, 2006·Annals of the New York Academy of Sciences·Cornelia M WeyandJörg J Goronzy
Nov 21, 2019·Scientific Reports·Takamichi YoshizakiSusumu Nakae
Apr 17, 2009·Analytical Chemistry·Amy L OuelletteGregory T A Kovacs

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Arthritis and Rheumatism
M TellusI Wicks
Rheumatic Diseases Clinics of North America
Maria C CidJ Hernández-Rodríguez
Clinics in Geriatric Medicine
William A Banks, Susan A Farr
Clinics in Geriatric Medicine
Alfred L Fisher, Renée Hill
© 2022 Meta ULC. All rights reserved