Arterial wall thickening and stiffening in children and adolescents with type 1 diabetes

Diabetes Research and Clinical Practice
Mehmet Emre AtabekMurat Baykara

Abstract

We evaluated structural and functional characteristics of the common carotid artery (CCA), a marker of early carotid atherosclerosis, and investigated their relation to metabolic and anthropometric parameters in children and adolescents with type 1 diabetes. Non-invasive ultrasonographic measurements were made in 45 type 1 diabetic patients and 33 controls. Age, sex, and body mass index were matched between patients and controls. We investigated intima-media thickness (IMT), compliance, distensibility, diastolic wall stress (DWS) and incremental elastic modulus (IEM) of the CCA. Metabolic and anthropometric parameters such as serum lipids, plasma glycated haemoglobin, body mass index, waist-hip ratio and blood pressure were assessed. The diabetic patients had significantly higher CCA-IMT than the controls (0.48+/-0.06mm versus 0.33+/-0.07mm; p<0.001). The diabetic children had significantly higher values than the controls for DWS (1.18+/-0.29mmHgx10(2) versus 0.81+/-0.25mmHgx10(2); p<0.001) and for IEM (1.26+/-0.57mmHgx10(3) versus 0.77+/-0.28mmHgx10(3); p<0.001). The difference was not significant between patients and controls for arterial compliance and for distensibility (p>0.05). In a multivariate regression model for all s...Continue Reading

References

Feb 19, 1998·Journal of Pediatric Endocrinology & Metabolism : JPEM·K C DonaghueD S Celermajer
Apr 16, 1998·Diabetes Care·J LambertC D Stehouwer
Jul 22, 1998·The Journal of Pediatrics·S OwensN A Le
Jan 29, 2002·Diabetes·Mikko J JärvisaloOlli T Raitakari
Oct 22, 2002·Journal of Pediatric Endocrinology & Metabolism : JPEM·Taner YavuzMine Sükür
Oct 11, 2005·Diabetes Research and Clinical Practice·Mehmet Emre AtabekMurat Baykara

❮ Previous
Next ❯

Citations

Jul 30, 2011·Cardiology in the Young·Mustafa Dogan, Elvan Caglar Citak
Feb 9, 2012·Experimental Diabetes Research·Yvonne SearlsLisa Stehno-Bittel
Aug 9, 2007·The Diabetes Educator·Lauren A GellarTonja R Nansel
Sep 14, 2011·Journal of Clinical Research in Pediatric Endocrinology·Mehmet Emre AtabekBülent Oran
Feb 21, 2013·International Journal of Medical Sciences·Maria Felicia FaienzaLuciano Cavallo
Oct 28, 2010·European Journal of Pediatrics·Christophe LamotteFrédéric Gottrand
Apr 25, 2013·Diabetes Research and Clinical Practice·Luca SabaUNKNOWN Fellow AIMBE
Aug 28, 2007·The Journal of Pediatrics·Robert Dalla PozzaHeinrich Netz
Oct 20, 2009·Diabetes/metabolism Research and Reviews·I BarchettaM G Cavallo
Oct 6, 2010·Diabetes/metabolism Research and Reviews·Ildikó VastaghAnikó Somogyi
May 23, 2014·Diabetes/metabolism Research and Reviews·Randhir SinghRakesh Gollen
Jun 12, 2009·Pediatric Diabetes·Robert Dalla PozzaSusanne Bechtold
Jul 30, 2015·Journal of Diabetes and Its Complications·Sevil Korkmaz-IcözGábor Szabó
May 9, 2015·The International Journal of Behavioral Nutrition and Physical Activity·Tonja R NanselAiyi Liu
Mar 13, 2014·Journal of Diabetes and Its Complications·Lindsay M JaacksElizabeth J Mayer-Davis
Apr 23, 2013·International Journal of Cardiology·David MonteroAgnès Vinet
Jun 10, 2010·Diabetes Care·Hanna Dis MargeirsdottirKnut Dahl-Jørgensen
Dec 26, 2007·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·T Brooks VaughanElaine Moreland
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·R Paul Wadwa
Mar 22, 2007·The Journal of Clinical Endocrinology and Metabolism·Robert Dalla PozzaHans-Peter Schwarz
May 29, 2020·Blood Pressure·Magdalena BłaszkowskaKrzysztof Narkiewicz
Jun 15, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ying ZhangPin Li
Jul 21, 2017·Archives of Endocrinology and Metabolism·Lúcia Helena Bonalume TacitoJuan Carlos Yugar-Toledo
Nov 9, 2014·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Mandy HoSarah P Garnett
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity
Dec 8, 2021·Journal of the American Heart Association·Joseph F PolakUNKNOWN DCCT/EDIC Research Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.