Arterio-venous access in end-stage renal disease patients and pulmonary hypertension

Therapeutic Advances in Respiratory Disease
Mordechai YiglaFarid Nakhoul

Abstract

The syndrome of pulmonary hypertension (PHT) in end-stage renal disease (ESRD) has been described in patients on chronic hemodialysis (HD) therapy via arterial-venous (A-V) access. However, the exact timing for the development of the PHT is unknown. This study was designed to evaluate changes in pulmonary artery pressure (PAP) following creation of the vascular access. PAP and cardiac-output (CO) values were recorded in 12 pre-dialysis patients without PHT a few months after the access formation, before treatment with HD was started, and the prevalence of PHT was calculated. Clinical data was compared between patients with and without PHT. The systolic PAP values were increased in "ve of the 12 pre-dialysis patients (42%) by 21+/-9 mm Hg to more than 35 mm Hg. Patients with and without PHT differed only in that CO was signi"cantly higher among the former. The development of PHT following access formation represents a failure of the pulmonary circulation to accommodate the access-mediated elevated CO. Pre-dialysis patients scheduled for access formation should be screened for the presence of sub-clinical PHT. "Positive" patients should proceed to peritoneal dialysis or advance to kidney transplantation; rather than getting acces...Continue Reading

References

Nov 1, 1989·The American Review of Respiratory Disease·B O Meyrick, E A Perkett
Nov 1, 1988·Progress in Cardiovascular Diseases·S Rich
May 14, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·R WeverT Rabelink
Jul 26, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S T MorrisA G Jardine
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·N D Vaziri
Aug 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael Robert ClarksonJohn Donohoe
May 13, 2003·Chest·Mordechai YiglaShimon A Reisner
Apr 21, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Farid NakhoulZaid Abassi
May 13, 2005·Chest·Eduardo BossoneLuigi Allegra
Oct 21, 2005·Chest·Michal Barak, Yeshayahu Katz

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Citations

Mar 26, 2011·Seminars in Dialysis·Dominic TrainorAndrew Ferguson
Nov 26, 2013·Clinics in Chest Medicine·Tim Lahm, Murali M Chakinala
Jun 7, 2013·Kidney International·Meghan E SiseRichard N Channick
Feb 13, 2009·Kidney International·Mordechai YiglaFarid Nakhoul
Sep 25, 2015·Pulmonary Circulation·Udhay KrishnanIrina Sobol
Nov 14, 2015·Hemodialysis International·Chin-Wen HsiehJung-Chou Wu
Mar 27, 2015·Seminars in Dialysis·Adrian Sequeira, Tze-Woei Tan
Mar 10, 2016·The Journal of Vascular Access·Bram M VoorzaatJoris I Rotmans
Mar 10, 2016·The Journal of Vascular Access·Ramon Roca-Tey
Oct 12, 2018·Current Cardiology Reviews·Mario NaranjoJanani Rangaswami
Mar 5, 2010·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·A DomeniciF Principe
Jul 14, 2020·Current Opinion in Nephrology and Hypertension·Daniel L Edmonston, Matthew A Sparks
Mar 28, 2018·International Urology and Nephrology·Weifeng ShangJunwu Dong
Apr 13, 2021·Frontiers in Medicine·Mazen Al-QadiH James Ford
Feb 26, 2020·Respiratory Medicine·Joe DevasahayamKulothungan Gunasekaran

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