PMID: 9537554Apr 16, 1998Paper

Arterio-venous extracorporeal membrane oxygenation of fetal goat incubated in artificial amniotic fluid (artificial placenta): influence on lung growth and maturation

Journal of Pediatric Surgery
M YasufukuM Okada

Abstract

The authors attempted to achieve extrauterine support of goat fetuses using arteriovenous extracorporeal membrane oxygenation (A-V ECMO) via umbilical vessels, incubated in a warm bath. They hypothesized that this extrauterine support system affected both the lung growth and maturation of goat fetuses. Four goat fetuses at about 125 days' gestation (term, 150 days) were placed in this fetal ECMO system. Their four twin fetuses with similar body weights were harvested and examined for baseline data before ECMO (pre-ECMO data). The mean duration of A-V ECMO was 138.8+/-66.9 hours (range, 87 to 237 hours). Tracheal ligation was performed on all four fetuses to prevent the efflux of fetal tracheal fluid and to collect a sample of tracheal fluid daily. The surfactant and electrolytes of the tracheal fluid were analyzed in pre-ECMO (twin fetuses) and during ECMO. The surfactant of lung tissue, and lung weight were analyzed in pre-ECMO (twin fetuses) and after ECMO. Plasma cortisol and T3 levels were also assayed as hormonal factors that affected lung maturation in pre-ECMO and during ECMO. The phospholipid, phosphatidylcholine, and lecithin-sphingomyelin ratio of the tracheal fluid on day 5 during ECMO (15.0+/-7.1 mg/dL, 53.4+/-26.5%...Continue Reading

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Citations

Mar 16, 2011·Annals of the New York Academy of Sciences·Carlo BullettiDominique de Ziegler
Jan 20, 2015·Journal of Pediatric Surgery·Benjamin BrynerGeorge Mychaliska
Apr 26, 2017·Nature Communications·Emily A PartridgeAlan W Flake
Mar 4, 2014·Seminars in Perinatology·Benjamin S Bryner, George B Mychaliska
May 3, 2014·Current Opinion in Pediatrics·Ryan P DavisGeorge B Mychaliska
Apr 27, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·M A SchwarzB R Pitt
Feb 27, 2016·Pediatric Pulmonology·Catarina Metelo-Coimbra, Roberto Roncon-Albuquerque
May 7, 2013·The International Journal of Artificial Organs·Niels RochowChristoph Fusch
Mar 1, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Brian W GrayGeorge B Mychaliska
Nov 20, 2020·Journal of Medical Ethics·Phillip Stefan Wozniak, Ashley Keith Fernandes
Jul 2, 2018·Journal of Pediatric Surgery·Joseph T ChurchGeorge B Mychaliska
May 30, 2017·Seminars in Fetal & Neonatal Medicine·Emily A PartridgeAlan W Flake

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