Arteriolar network growth in rat striated muscle during juvenile maturation

International Journal of Microcirculation, Clinical and Experimental
J R Linderman, M A Boegehold

Abstract

To better understand normal microvascular network growth, we conducted a longitudinal study on the spinotrapezius muscle of Sprague-Dawley rats of 3 ages: weanling (3-4 weeks), juvenile (7-8 weeks) and mature (11-12 weeks). Morphometric analysis revealed that despite dramatic growth of the muscle (from 117 +/- 60 mg in weanling to 417 +/- 112 mg in mature rats), there is no significant change in the total number of arcade arteriole segments per network over this period (from 140 +/- 35 to 181 +/- 51). The mean arcade segment length increased over this period (from 0.96 +/- 0.17 to 1.45 +/- 0.32 mm), but not in proportion to tissue growth. Consequently, the total arcade segment length per unit muscle volume significantly decreased (from 1.36 +/- 0.48 to 0.66 +/- 0.12 mm/mm3). The estimated number of transverse arteriolar trees per muscle (approximately 600) did not appreciably change with growth, leading to a decrease in the number of trees per millimeter arcade arteriole (from 4.4 +/- 1.2 to 2.3 +/- 0.6). Transverse arteriolar trees underwent age-dependent increases in the number of segments within each branch order and in mean segment length. These observations suggest that arteriolar network growth during juvenile maturation ...Continue Reading

Citations

Sep 4, 2004·Environmental Health Perspectives·Timothy R NurkiewiczMatthew A Boegehold
Aug 13, 2009·Journal of Vascular Research·Julie Balch SamoraMatthew A Boegehold
Jul 14, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Matthew A Boegehold
Mar 23, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Geraldine F Clough, Mikael Norman
Jun 20, 2014·European Journal of Clinical Investigation·Oliver SchlagerMichael E Gschwandtner
Apr 28, 2005·Journal of Vascular Research·Paul J MarvarMatthew A Boegehold
Sep 9, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Leah W Hammer, Matthew A Boegehold
Nov 23, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Paul J MarvarMatthew A Boegehold
Oct 12, 1999·The American Journal of Physiology·J R Linderman, M A Boegehold
Jan 27, 1998·Current Opinion in Nephrology and Hypertension·M A Boegehold
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·B VollmarM D Menger
Aug 29, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Julie Balch SamoraMatthew A Boegehold
Apr 1, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Julie Balch SamoraMatthew A Boegehold

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