Arteriosclerotic events are less frequent in persons with chronic anemia: evidence from families with hereditary spherocytosis

American Journal of Hematology
R F SchillingMyrna Traver

Abstract

Because anemic persons have lower cholesterol and whole blood viscosity than those who are not anemic, we hypothesized that subjects with hereditary spherocytosis who have not had the spleen removed should have fewer arteriosclerotic events than unaffected family members. We defined arteriosclerotic events as myocardial infarct, stroke, coronary artery surgery, and carotid artery surgery. We compared the rate of these events in affected-not splenectomized persons to the rate in unaffected family members. The relative risk of an arteriosclerotic event in hereditary spherocytosis patients with a spleen was one fifth that in unaffected family members. These data support the hypothesis that chronic anemia retards the development of arteriosclerosis. Spherocytosis is another example of an inherited condition that conveys an advantage in one system and a disadvantage in another.

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Citations

Mar 24, 2010·Pediatric Surgery International·Ram KalpatthiSherron M Jackson
Jul 29, 2009·Blood·Shelley E Crary, George R Buchanan
Oct 23, 2008·Lancet·Silverio PerrottaNarla Mohandas
May 20, 2008·Journal of Thrombosis and Haemostasis : JTH·R F SchillingM I Traver
Jul 1, 2010·Pediatric Blood & Cancer·Shelley E CraryGeorge R Buchanan
Nov 8, 2011·British Journal of Haematology·Paula H B Bolton-MaggsUNKNOWN General Haematology Task Force of the British Committee for Standards in Haematology
Oct 14, 2006·American Journal of Hematology·Hanna ShalevHannah Tamary
Sep 15, 2007·Pediatric Blood & Cancer·Sarah B TroendleGeorge R Buchanan
Jan 3, 2020·Journal of Pediatric Hematology/oncology·Zeynep C ÖzdemirÖzcan Bör
Nov 15, 2011·Expert Review of Hematology·Maddalena Casale, Silverio Perrotta
Sep 5, 2021·Current Neurology and Neuroscience Reports·Ana Catarina FonsecaJosé M Ferro

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