Arterolane maleate plus piperaquine phosphate for treatment of uncomplicated Plasmodium falciparum malaria: a comparative, multicenter, randomized clinical trial

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Neena ValechaNilanjan Saha

Abstract

Artemisinin-based combination therapy is the first-line treatment for uncomplicated falciparum malaria. This study assessed the antimalarial efficacy and safety of a combination of 150 mg of arterolane maleate and 750 mg of piperaquine phosphate (AM-PQP) in comparison to Coartem (artemether and lumefantrine) in patients with acute uncomplicated P. falciparum malaria. In this open-label, randomized, multicentric, parallel group clinical trial, 240 patients were randomized to receive AM-PQP (160 patients) or Coartem (80 patients). Patients with P. falciparum monoinfection and initial parasite densities ranging from 1000 to 100 000 asexual parasites/µL of blood were followed for 28 days. Polymerase chain reaction-corrected adequate clinical and parasitologic response on day 28, parasite clearance time, and fever clearance time were evaluated. A total of 151 (94.4%) of 160 patients in the AM-PQP group completed the trial, while 77 (96.3%) of 80 patients in the Coartem group completed the trial. No treatment failure was noted in the AM-PQP group, while one patient receiving Coartem failed treatment on day 28. There was no difference in the median parasite clearance time (30 hours in both groups) or median fever clearance time (24 ho...Continue Reading

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Citations

Jun 18, 2015·Expert Review of Anti-infective Therapy·Abdoulaye A DjimdeKamal Hamed
Apr 11, 2014·Expert Review of Clinical Pharmacology·Brian Angus
Jan 8, 2015·Expert Opinion on Investigational Drugs·Jana HeldAndrea Kreidenweiss
Feb 26, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Offianan Andre TourePaul Swoboda
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Jun 13, 2016·Trends in Parasitology·Leann TilleyDavid A Fidock
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Nov 5, 2016·Infectious Diseases of Poverty·Akshaya Srikanth BhagavathulaAbdulla Shehab
Jan 5, 2017·Journal of Medicinal Chemistry·Yuxiang DongJonathan L Vennerstrom
Apr 13, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew M IppolitoPhilip J Rosenthal
Dec 22, 2017·Antimicrobial Agents and Chemotherapy·Carlo GiannangeloDarren J Creek
Oct 3, 2017·Expert Review of Clinical Pharmacology·Jane AchanUmberto D'alessandro
Oct 24, 2019·The American Journal of Tropical Medicine and Hygiene·Matthew R Hassett, Paul D Roepe
Jun 3, 2016·Expert Review of Anti-infective Therapy·Johannes MischlingerMichael Ramharter
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Jun 9, 2021·ACS Infectious Diseases·David M ShacklefordSusan A Charman
Dec 13, 2016·Journal of Medicinal Chemistry·Benjamin SpanglerAdam R Renslo

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