Artery-vein specification in the zebrafish trunk is pre-patterned by heterogeneous Notch activity and balanced by flow-mediated fine-tuning.

Development
Ilse GeudensHolger Gerhardt

Abstract

How developing vascular networks acquire the right balance of arteries, veins and lymphatic vessels to efficiently supply and drain tissues is poorly understood. In zebrafish embryos, the robust and regular 50:50 global balance of intersegmental veins and arteries that form along the trunk prompts the intriguing question of how does the organism keep 'count'? Previous studies have suggested that the ultimate fate of an intersegmental vessel (ISV) is determined by the identity of the approaching secondary sprout emerging from the posterior cardinal vein. Here, we show that the formation of a balanced trunk vasculature involves an early heterogeneity in endothelial cell behaviour and Notch signalling activity in the seemingly identical primary ISVs that is independent of secondary sprouting and flow. We show that Notch signalling mediates the local patterning of ISVs, and an adaptive flow-mediated mechanism subsequently fine-tunes the global balance of arteries and veins along the trunk. We propose that this dual mechanism provides the adaptability required to establish a balanced network of arteries, veins and lymphatic vessels.

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Citations

Jun 26, 2020·Frontiers in Physiology·Pedro CampinhoJulien Vermot
Aug 10, 2020·Development·Margo DaemsElizabeth A V Jones
Aug 15, 2020·Frontiers in Physiology·Kazuhide S Okuda, Benjamin M Hogan
Feb 5, 2021·PLoS Computational Biology·Lowell T EdgarMiguel O Bernabeu
Jan 15, 2021·Journal of Cell Science·Oscar M J A StassenCecilia M Sahlgren
Mar 11, 2021·Cellular and Molecular Life Sciences : CMLS·Timothy J A Chico, Elisabeth C Kugler
Mar 4, 2021·Current Opinion in Hematology·Andreia PenaCláudio Areias Franco
Mar 15, 2021·Current Opinion in Hematology·Claudia Jasmin Rödel, Salim Abdelilah-Seyfried
Apr 1, 2021·British Journal of Pharmacology·George BowleyJovana Serbanovic-Canic

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Datasets Mentioned

BETA
GM130

Methods Mentioned

BETA
transgenic
transgenesis
flow cytometry

Software Mentioned

Python
Fiji
Matlab
ImageJ
Prism ( GraphPad

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