Artesunate alleviates hepatic fibrosis induced by multiple pathogenic factors and inflammation through the inhibition of LPS/TLR4/NF-κB signaling pathway in rats

European Journal of Pharmacology
Lina LaiXiaoliang Song

Abstract

The current study was performed in order to explore the effect of artesunate (Art) on experimental hepatic fibrosis and the potential mechanism involved. Art, a water-soluble hemisuccinate derivative of artemisinin extracted from the Chinese herb Artemisia Annua, is a safe and effective antimalarial drug. Hepatic fibrosis was induced in SD rats by multiple pathogenic factors. Rats were treated concurrently with Art (28.8 mg/kg) given daily by oral gavage for 6 or 8 weeks to evaluate its protective effects. Our data demonstrated that Art treatment obviously attenuated hepatic fibrosis, characterized by less inflammatory infiltration and accumulation of extracellular matrix (ECM). Art remarkably decreased endotoxin, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) levels as well. Art significantly downregulated protein and mRNA expression of α-smooth muscle actin (α-SMA), toll-like receptors 4 (TLR4), myeloid differentiation factor 88 (MyD88) and transforming growth factor beta 1 (TGF-β1). Art also significantly inhibited the nuclear transcription factor kappa B p65 (NF-κB p65) translocation into the nucleus. In addition, there were no remarkable differences between the N group and the NA group. In conclusion, we found t...Continue Reading

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Citations

Feb 2, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Rui-Jie MaGang Zhou
Mar 6, 2019·Cardiovascular Toxicology·Ashkan Kalantary-CharvadehSaeed Nazari Soltan Ahmad
Oct 18, 2018·BMC Pharmacology & Toxicology·Jian LvHong Zhang
Dec 19, 2019·Journal of Orthopaedic Surgery and Research·Hui ChenLianqi Yan
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhaoyan KongYuanrong Cheng
Mar 2, 2021·Acta Pharmaceutica Sinica. B·David DolivoTanja Dominko
Dec 12, 2017·Environmental Toxicology and Pharmacology·Xinyang LiZunzhen Zhang

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