Abstract
Inflammatory response is important for the development and progression of diabetic nephropathy (DN). Artesunate (ART), an antimalarial drug, possesses anti-inflammatory effect and exhibits protective effect on chronic kidney diseases. However, the effect of ART on DN is unknown. The aim of the present study was to evaluate the effect and the molecular mechanism of ART on DN in an in vitro model. The rat mesangial cell line, HBZY-1, was induced by high glucose (HG; 30 mM d-glucose) in the presence or absence of ART (15 and 30 μg/ml) and incubated for 24 h. We found that HG induced the proliferation of HBZY-1 cells, while treatment with ART inhibited the cell proliferation. Treatment with ART inhibited HG-induced inflammatory cytokines production and expression of extracellular matrix (ECM). Besides, HG induced reactive oxygen species (ROS) and malondialdehyde (MDA) levels, and inhibited the superoxide dismutase (SOD) activity of HBZY-1 cells, and the effects were attenuated by ART treatment. ART decreased HG-induced the expression levels of toll-like receptor 4 (TLR4), myeloid differentiation primary response gene 88 (MyD88), nuclear factor κB (NF-κB) p-p65, and nod-like receptor protein 3 (NLRP3). Inhibition of the TLR4/NF-κB p...Continue Reading
Citations
Dec 7, 2018·Canadian Journal of Physiology and Pharmacology·Firouzeh GholampourZeinab Karimi
Dec 28, 2019·Journal of Cellular and Molecular Medicine·Liangjun LiWeiling Li
Sep 25, 2019·Journal of Cellular Physiology·Mo LiXuan Zhang
Oct 28, 2019·Acta Pharmacologica Sinica·Lei DuQian Lu
Feb 20, 2020·Clinical and Experimental Pharmacology & Physiology·Zhu WangJie Chen
Aug 25, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Chien-Wen ChianHuei-Jane Lee
May 16, 2019·Neural Regeneration Research·Bing-Wen LuLi-Ke Xie
May 16, 2019·Journal of Cellular Physiology·Bin ChenZhonggao Xu
Nov 7, 2019·Cells·Yang Gyun KimJu-Young Moon
Apr 17, 2020·Frontiers in Pharmacology·Ming XiaHong Liu
May 24, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jinghui ZhaiSixi Zhang
Aug 29, 2020·European Journal of Pharmacology·Chetan RamBidya Dhar Sahu
Nov 7, 2020·Trends in Parasitology·Sanjeev KrishnaPeter Kremsner
Jan 28, 2021·BMC Endocrine Disorders·Yi ChenShiying Yang
Oct 12, 2019·Life Sciences·Hongjiao DuXiaodong Li
Jan 1, 2021·Frontiers in Pharmacology·Ya-Yi JiangRen-Song Yue
Jan 5, 2021·Biological & Pharmaceutical Bulletin·Yanlin ChenYili Wang
Mar 5, 2021·Archives of Physiology and Biochemistry·Lihua LiLei Chen
Mar 2, 2021·Acta Pharmaceutica Sinica. B·David DolivoTanja Dominko
Jun 1, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Jingjing GuoPingshuan Dong
May 22, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qi HuangDongsheng Ouyang
Jun 21, 2021·Medicinal Research Reviews·Yuqing MengJigang Wang
Jul 22, 2021·Medicinal Research Reviews·Thomas Efferth, Franz Oesch
Jul 27, 2021·Frontiers in Immunology·Wei XiongChun Zhang
Nov 10, 2021·Journal of Cellular Physiology·Pan MiaoSun Chao