Abstract
Blood-brain barrier preservation plays an important role in attenuating vasogenic brain edema after subarachnoid hemorrhage (SAH). This study was designed to investigate the protective effect and mechanism of artesunate, a traditional anti-malaria drug, on blood-brain barrier after SAH. Three hundred and seventy-seven (377) male Sprague-Dawley rats were subjected to endovascular perforation model for SAH. The rats received artesunate alone or in combination with Sphingosine-1-phosphate receptor-1 (S1P1) small interfering RNA (siRNA), antagonist VPC23019, or phosphatidylinositol 3-kinase inhibitor wortmannin after SAH. Modified Garcia score, SAH grades, brain water content, Evans blue leakage, transmission electron microscope, immunohistochemistry staining, Western blot, and cultured endothelial cells were used to investigate the optimum concentration and the therapeutic mechanism of artesunate. We found that artesunate (200 mg/kg) could do better in raising modified Garcia score, reducing brain water content and Evans blue leakage than other groups after SAH. Moreover, artesunate elevated S1P1 expression, enhanced phosphatidylinositol 3-kinase activation, lowered GSK-3β activation, stabilized β-catenin, and improved the express...Continue Reading
References
Apr 1, 1995·Stroke; a Journal of Cerebral Circulation·J H GarciaX J Hu
Jul 10, 2003·Lancet Neurology·Valery L FeiginCraig S Anderson
Dec 6, 2005·Antiviral Research·Suzanne J F KapteinManfred Marschall
Sep 26, 2006·Immunopharmacology and Immunotoxicology·A MirshafieyS Cuzzocrea
Sep 4, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jianqing ZhangMary O Gray
Sep 18, 2007·Journal of Neuroscience Methods·Takashi SugawaraJohn H Zhang
Jul 8, 2008·Nature Cell Biology·Andrea TaddeiElisabetta Dejana
May 16, 2009·Current Drug Metabolism·Anirudh GautamJyoti Paliwal
Nov 27, 2009·Stroke; a Journal of Cerebral Circulation·Yu HasegawaJohn H Zhang
May 29, 2010·Stroke; a Journal of Cerebral Circulation·Yilin ZhouJohn H Zhang
Jul 10, 2010·Stroke; a Journal of Cerebral Circulation·Hidenori SuzukiJohn H Zhang
Oct 15, 2010·International Journal of Hematology·Hao ChenLing Pan
Oct 30, 2010·Annals of Neurology·Hidenori SuzukiJohn H Zhang
May 4, 2011·International Journal of Oncology·Oranuch ThanaketpaisarnIkuo Saiki
May 11, 2011·Molecular Medicine·Constance Am FinneyKevin C Kain
Jun 23, 2011·PloS One·Chang ChengW S Fred Wong
Jul 5, 2011·Acta Neurochirurgica. Supplement·William B RollandJohn H Zhang
Oct 19, 2011·Toxicology Mechanisms and Methods·Wardah Yusof, Gan Siew Hua
Dec 14, 2011·Annual Review of Immunology·Jason G Cyster, Susan R Schwab
Mar 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bo LiHua Feng
Apr 11, 2012·Critical Care Medicine·Orhan AltayJohn H Zhang
Oct 25, 2012·Journal of Neurochemistry·Basak CanerJohn H Zhang
Oct 17, 2012·Nature Reviews. Neurology·John H ZhangWilliam J Pearce
Oct 26, 2012·Malaria Research and Treatment·Mariana C SouzaMaria das Graças M O Henriques
Apr 17, 2013·Physiological Reviews·Dorothee Günzel, Alan S L Yu
Apr 25, 2013·Stroke; a Journal of Cerebral Circulation·Paul R KrafftJohn H Zhang
Jun 15, 2013·Trends in Pharmacological Sciences·Catherine O'Sullivan, Kumlesh K Dev
Jul 3, 2013·Oncology Reports·Fei ZhaoTao Liu
Oct 1, 2013·Progress in Neurobiology·Sheng ChenJohn H Zhang
Dec 19, 2013·Development·Karen MendelsonTimothy Hla
Jun 6, 2014·Journal of Biomedical Science·Divya AryaThomas N Tulenko
Aug 26, 2014·Molecular Neurobiology·Sheng-Li HuHua Feng
Dec 18, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Dongsheng WuIgnacio A Romero
Dec 18, 2014·Malaria Journal·Anne MarijonStéphane Picot
Dec 24, 2014·Journal of Molecular Neuroscience : MN·Fatemeh SafarianLeila Dargahi
Jan 1, 2015·Stroke; a Journal of Cerebral Circulation·Yujie ChenJohn H Zhang
Mar 19, 2015·Stroke; a Journal of Cerebral Circulation·Fan YangHua Feng
Citations
Oct 23, 2018·Journal of Neuroscience Research·Pinar Eser OcakJiping Tang
Feb 26, 2019·Neural Regeneration Research·Hideki Kanamaru, Hidenori Suzuki
Jun 29, 2017·Pharmacological Reviews·Anna CooperAndrea J Vernall
Apr 16, 2020·Cell Communication and Signaling : CCS·Yunxiang ZhouJianmin Zhang
May 8, 2020·Aging·Kaiyuan ZhangHua Feng
Jan 14, 2020·Journal of Neuroinflammation·Pengyu PanYujie Chen
May 4, 2017·Molecular Neurobiology·Li LinZhanyang Yu
Jul 10, 2018·Molecular Neurobiology·T Peeyush KumarSpiros L Blackburn
Jun 21, 2018·Frontiers in Neurology·Qiang LiHua Feng
Jan 25, 2017·BioMed Research International·Shilun ZuoYujie Chen
May 8, 2018·Inflammation·Zhaohui LiuYulin Chang
Apr 3, 2019·Chinese Medical Journal·Zhan-Ying YePei-Yuan Lv
Sep 15, 2020·Frontiers in Cellular and Infection Microbiology·Gunanidhi Dhangadamajhi, Shailja Singh
Aug 1, 2020·Frontiers in Neurology·Gen LiGuobiao Liang
Oct 20, 2020·Frontiers in Physiology·Romain MenetAyman ElAli
Nov 11, 2020·Aging·Shenquan GuoChuanzhi Duan
Dec 19, 2020·Translational Neuroscience·Zhike ZhouQinghua Li
Jan 5, 2021·Biological & Pharmaceutical Bulletin·Yanlin ChenYili Wang
Mar 16, 2021·Frontiers in Cellular Neuroscience·Ju WangLiang Tan
Mar 14, 2021·Experimental Neurology·Xufang RuHua Feng
May 1, 2021·Brain Research·İlker GüleçTevhide Bilgen Özcan
Jan 7, 2020·Current Neuropharmacology·Yuchen LiHuaizhang Shi