Arthralgias and cryoglobulinemia during protease inhibitor therapy in a patient infected with human immunodeficiency virus and hepatitis C virus

Arthritis and Rheumatism
J J MonsuezBrigitte Autran

Abstract

We present the case of a woman who had a chronic infection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV). She developed severe polyarthralgias associated with type II mixed cryoglobulinemia during therapy with an HIV-1 protease inhibitor. This therapy resulted in a dramatic increase in her CD4+ T cell count, from 70/mm3 to 567/mm3, which was composed of a high proportion (88%) of naive CD45RA+ CD62L+ cells, together with a recovery of her CD4+ T cell reactivity to antigenic stimulation. This may suggest that rapid recovery of immune competence in the CD4+ T helper subset might participate in the development of immunopathologic events such as this patient's cryoglobulinemia.

References

Jun 15, 1996·Annals of Internal Medicine·J M SchapiroT C Merigan
Jun 15, 1996·Annals of Internal Medicine·J G Bartlett
Jul 27, 1996·Lancet·M B Feinberg
Feb 12, 1998·Annals of Internal Medicine·R MisianiD Primi

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Citations

Nov 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P BlancheD Sicard
Jan 19, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laurent AaronJean-Paul Viard
Mar 22, 2006·AIDS·David SaadounUNKNOWN GERMIVIC Study Group
Feb 28, 2015·Viral Immunology·Magdalena Rogalska-PłońskaRobert Flisiak
May 26, 2009·Actas dermo-sifiliográficas·M BlanesJ Portilla
Feb 8, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Evy YunihastutiPatricia Price
Aug 24, 2013·International Journal of STD & AIDS·Samar OjaimiIan Woolley
Aug 24, 2006·Journal of Medical Virology·Nikolaos KosmasTheodore Kordossis

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