Arthritis and pneumonitis produced by the same T cell clones from mice with spontaneous autoimmune arthritis

International Immunology
Chiaki Wakasa-MorimotoS Sakaguchi

Abstract

SKG mice, a newly established model of rheumatoid arthritis (RA), spontaneously develop autoimmune arthritis accompanying extra-articular manifestations, such as interstitial pneumonitis. To examine possible roles of T cells for mediating this systemic autoimmunity, we generated T cell clones from arthritic joints of SKG mice. Two distinct CD8(+) clones were established and both showed in vitro autoreactivity by killing syngeneic synovial cells and a variety of MHC-matched cell lines. Transfer of each clone to histocompatible athymic nude mice elicited joint swelling and histologically evident synovitis accompanying the destruction of adjacent cartilage and bone. Notably, the transfer also produced diffuse severe interstitial pneumonitis. Clone-specific TCR gene messages in the inflamed joints and lungs of the recipients gradually diminished, becoming hardly detectable in 6-11 months; yet, arthritis and pneumonitis continued to progress. Thus, the same CD8(+) T cell clones from arthritic lesions of SKG mice can elicit both synovitis and pneumonitis, which chronically progress and apparently become less T cell dependent in a later phase. The results provide clues to our understanding of how self-reactive T cells cause both artic...Continue Reading

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Apr 4, 2009·Current Opinion in Rheumatology·Vincent GoëbPaul Emery
Feb 2, 2013·American Journal of Respiratory Cell and Molecular Biology·Rebecca A ShillingHaochu Huang
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Jul 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Satoshi TanakaShimon Sakaguchi

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