Arthritis of mice induced by Mycoplasma pulmonis: humoral antibody and lymphocyte responses of CBA mice.

Infection and Immunity
B C ColeJ R Ward

Abstract

Peak arthritis occurred 14 days after intravenous injection of Mycoplasma pulmonis and persisted in some mice at low levels for 84 days. A marked lymphocytosis occurred during the first week of infection with only a slight increase in polymorphonuclear leukocytes. Complement-fixing antibodies appeared in low titer 3 days after infection and moderate levels persisted for 84 days. The metabolic-inhibiting and mycoplasmacidal antibody responses were absent or minimal. M. pulmonis appeared to be mitogenic for mouse lymphocytes as evidenced by (i) increased uptake of [3H]thymidine for normal lymphocytes exposed to various concentrations of nonviable M. pulmonis antigen, and (ii) a 13-fold increase in [3H]thymidine uptake in lymphocytes taken from mice 3 days after infection with M. pulmonis in the absence of added antigen. Lymphocytes taken from infected mice transformed significantly more at all time periods than control lymphocytes when exposed to M. pulmonis antigen. This response was maximal at 3 days and minimal at 21 to 35 days after infection. Lymphocytes sensitized to M. pulmonis did not transform when exposed to M. arthritidis antigen or vice versa. M. pulmonis infection had no effect upon the mitogenic responses of lympho...Continue Reading

References

Jul 1, 1974·Annals of the Rheumatic Diseases·S M StewartW R Alexander
Dec 5, 1973·Nature: New Biology·H Ginsburg, J Nicolet
Jul 1, 1974·Annals of the Rheumatic Diseases·G TaylorG Slavin
Feb 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·T C JonesJ G Hirsch
Aug 1, 1972·Journal of Medical Microbiology·F W DennyA C Allison
Aug 1, 1972·European Journal of Immunology·J AnderssonG Möller
Mar 1, 1973·The Journal of Infectious Diseases·G J HallerN L Somerson
Jun 1, 1974·The Journal of Experimental Medicine·P H LagrangeT E Miller
Mar 1, 1973·Arthritis and Rheumatism·B C ColeC B Smith
Oct 1, 1973·The Journal of Infectious Diseases·H J HarwickL B Guze
Nov 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·H J HarwickL B Guze
Jun 1, 1968·Journal of Bacteriology·B C ColeC H Martin
Feb 1, 1971·The Journal of Experimental Medicine·T C Jones, J G Hirsch
Sep 1, 1969·Journal of General Microbiology·R M LemckeR J Fallon
Oct 1, 1969·Journal of Bacteriology·J A Barden, J G Tully
Jun 1, 1969·Journal of Bacteriology·R J Manchee, D Taylor-Robinson
Jan 15, 1962·Proceedings of the National Academy of Sciences of the United States of America·R M CHANOCKM F BARILE
Jun 1, 1970·Infection and Immunity·L Golightly-RowlandB B Wiley
Oct 1, 1970·Infection and Immunity·B C ColeB B Wiley

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Citations

Jun 1, 1977·Annals of the Rheumatic Diseases·G Taylor, D Taylor-Robinson
Jul 1, 1978·Infection and Immunity·Y Naot, S Merchav
Aug 1, 1985·Infection and Immunity·L R WashburnL K Roberts
Jul 1, 1976·Infection and Immunity·B C ColeL A Glasgow
Jan 1, 1995·Infection and Immunity·Z LapidotY Naot

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