Arthrogryposis Multiplex Congenita Related to Third-Trimester Basal Ganglia Ischemia: A Case Report

Child Neurology Open
Perrine VenotNathalie Bednarek

Abstract

Arthrogryposis multiplex congenita is a syndromic condition defined by contracture of 2 or more joints. A large range of etiologies has been reported such as neuromuscular disorders (peripheral dysfunction), chromosomal abnormalities, or cerebral malformations (central dysfunction) leading to fetal immobility. Severity of arthrogryposis depends on the etiology and duration of fetal immobility. The authors report a 34 gestational weeks infant presenting with severe diffuse arthrogryposis symptoms and respiratory failure at birth. Her mother experienced cardiac arrest at 29 gestational weeks due to carbon monoxide intoxication. Fetal magnetic resonance imaging revealed extensive corticospinal tract lesions. Antenatal ischemia of the deep gray matter needs to be considered as a possible arthrogryposis cause.

References

Jan 30, 2002·The Journal of Pediatrics·Niklas DarinMár Tulinius
Aug 28, 2007·Journal of the Neurological Sciences·Leon D Prockop, Rossitza I Chichkova
Oct 11, 2012·ISRN Obstetrics and Gynecology·Emmanouil KalampokasDimitrios Botsis
Apr 9, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·E Bothuyne-QuesteD Subtil

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