Arthrogryposis Multiplex Congenita.

Pediatric Annals
Seth Langston, Alison Chu

Abstract

Arthrogryposis multiplex congenita (AMC) is a complex, etiologically diverse, clinical descriptor identified in a variety of diagnoses characterized by multiple congenital joint contractures. The root cause of AMC is decreased fetal movement in-utero, whether resulting from maternal or pregnancy influences, nervous system pathology, or an underlying genetic abnormality. Prenatal diagnosis via ultrasonography can be challenging and may require additional imaging techniques or studies. After birth, these infants may require assistance breathing and feeding depending on the underlying diagnosis. Physical therapy and surgical intervention of the contractures are the mainstays of therapy, and outcomes can be good when intervention is provided in a timely manner. Those infants with syndromic causes of arthrogryposis are more likely to have poor outcomes; therefore, determining the underlying etiology for AMC is important as this can influence counseling regarding individual prognosis as well as future pregnancies. [Pediatr Ann. 2020;49(7):e299-e304.].

References

Aug 3, 2005·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·Ulrich MennenGeorge Gericke
Aug 8, 2006·American Journal of Medical Genetics. Part a·Niklas PakkasjärviJaakko Ignatius
Jun 23, 2007·Journal of Pediatric Orthopedics·Wesley P BevanKit Song
Aug 12, 2009·Journal of Children's Orthopaedics·Alice FassierRaphaël Seringe
Mar 19, 2011·Journal of Pediatric Orthopedics·Courtney J AmorGloria R Gogola
Sep 14, 2012·Journal of Multidisciplinary Healthcare·Moutasem M ObeidatWadah Khriesat
Sep 17, 2015·American Journal of Medical Genetics. Part a·Andreas R JaneckeBeat Steinmann
Oct 21, 2015·Journal of Children's Orthopaedics·Jana Midelfart Hoff, Anna Midelfart
Nov 6, 2015·Journal of Children's Orthopaedics·Eva Kimber
Mar 1, 2016·Archives of Medical Science : AMS·Bartłomiej Kowalczyk, Jarosław Feluś
Aug 12, 2016·BMJ : British Medical Journal·Vanessa van der LindenRegina Coeli Ramos
Sep 1, 2016·Italian Journal of Pediatrics·Raffaele FalsaperlaPiero Pavone
Sep 29, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Priya SkariaAtif Ahmed
Jun 9, 2018·Journal of Child Neurology·Alexander ConantAdeline Vanderver
Jul 4, 2019·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Scott OishiTerri Beckwith
Jul 19, 2019·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Isabel FilgesJudith G Hall
Aug 2, 2019·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Klaus DieterichPhilip Giampietro
Aug 15, 2019·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Klaus DieterichJudith G Hall
Aug 28, 2019·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Sarah CachechoNoémi Dahan-Oliel
Sep 4, 2019·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Reggie C HamdyMark Eidelman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.