Arthroscopic three dimensional autologous chondrocyte transplantation with navigation-guided cartilage defect size assessment

Archives of Orthopaedic and Trauma Surgery
Johannes ZellnerPeter Angele

Abstract

The treatment of large full thickness cartilage defects with matrix guided autologous chondrocyte transplantation shows promising results. However, in many cases an arthrotomy is needed to implant the cell seeded scaffolds. Recently techniques have been developed for arthroscopically guided ACT implantation. Correct defect mapping, to assess size and depth of the chondral lesions, and precise scaffold preparation and fixation are crucial for successful chondrocyte transplantation and remain to be not sufficiently optimized. In the present study, the geometries of two cartilage defects in cadaver knees were three times assessed, measured and transferred to biodegradable scaffolds with a navigation system by three different executors. The scaffolds were arthroscopically implanted into the cartilage defects. The cartilage defect assessment was reproducible between all executors for all defect geometries. The implanted scaffolds showed a correct defect filling. The study showed the feasibility of an arthroscopic implantation of scaffolds for autologous chondrocytes transplantation. Navigation was a useful tool to exactly assess the cartilage defect geometry and allowed a precise transfer of navigated cartilage defect geometries for...Continue Reading

References

Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson
May 20, 2000·Clinical Orthopaedics and Related Research·L PetersonA Lindahl
Jan 19, 2002·The American Journal of Sports Medicine·Lars PetersonAnders Lindahl
May 16, 2002·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·M MarcacciI Loreti
Jan 11, 2003·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Christoph ErggeletAndreas Lahm
May 2, 2003·The Journal of Bone and Joint Surgery. American Volume·Lars PetersonAnders Lindahl
Oct 22, 2005·Clinical Orthopaedics and Related Research·Michael Bolognesi, Aaron Hofmann
Mar 25, 2006·The American Journal of Sports Medicine·Stephan PlaweskiPhilippe Merloz
Apr 29, 2006·The Journal of Bone and Joint Surgery. British Volume·R P PittoI A Anderson
May 17, 2007·Archives of Orthopaedic and Trauma Surgery·Wolf PetersenThore Zantop
Oct 6, 2007·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Sandra ZelleWolf Petersen
May 16, 2008·Sports Medicine and Arthroscopy Review·Yasuyuki IshibashiSatoshi Toh
Oct 16, 2010·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Philipp NiemeyerNorbert P Südkamp
Jun 1, 2011·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Mirco HerbortThore Zantop

❮ Previous
Next ❯

Citations

Apr 22, 2014·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Clemente IbarraLuis G Ibarra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.