Articular cartilage MR imaging and thickness mapping of a loaded knee joint before and after meniscectomy

Osteoarthritis and Cartilage
Y SongN J Giori

Abstract

We describe a technique to axially compress a sheep knee joint in an MRI scanner and measure articular cartilage deformation. As an initial application, tibial articular cartilage deformation patterns after 2 h of static loading before and after medial meniscectomy are compared. Precision was established for repeated scans and repeated segmentations. Accuracy was established by comparing to micro-CT measurements. Four sheep knees were then imaged unloaded, and while statically loaded for 2 h at 1.5 times body weight before and after medial meniscectomy. Images were obtained using a 3D gradient echo sequence in a 4.7 T MRI. Corresponding 3D cartilage thickness models were created. Nominal strain patterns for the intact and meniscectomized conditions were compared. Coefficients of variation were all 2% or less. Root mean squared errors of MR cartilage thickness measurements averaged less than 0.09 mm. Meniscectomy resulted in a 60% decrease in the contact area (P=0.001) and a 13% increase in maximum cartilage deformation (P=0.01). Following meniscectomy, there were greater areas of articular cartilage experiencing abnormally high and low nominal strains. Areas of moderate nominal strain were reduced. Medial meniscectomy resulted ...Continue Reading

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Citations

Feb 4, 2014·The Knee·Bertrand Sonnery-CottetPierre Chambat
Jul 17, 2009·Journal of Biomechanical Engineering·K J MartinM L Hull
Jan 15, 2013·Rheumatic Diseases Clinics of North America·David R WilsonJames D Johnston
Dec 14, 2011·Bone·Hillary J Braun, Garry E Gold
Dec 18, 2009·Journal of Biomechanics·Laura L GreavesDavid R Wilson
Nov 26, 2009·Rheumatic Diseases Clinics of North America·David J Hunter, David R Wilson
Nov 26, 2009·Rheumatic Diseases Clinics of North America·Martin EnglundL Stefan Lohmander
Jul 28, 2009·Radiologic Clinics of North America·David J Hunter, David R Wilson
Jul 28, 2009·Radiologic Clinics of North America·Martin EnglundStefan L Lohmander
Dec 9, 2008·The Medical Clinics of North America·David R WilsonJames D Johnston
Aug 9, 2008·Rheumatic Diseases Clinics of North America·David R WilsonJames D Johnston
May 29, 2013·Veterinary Surgery : VS·Jean-Michel VandeweerdJean-Francois Nisolle
Mar 29, 2014·Journal of Magnetic Resonance Imaging : JMRI·Lauren M ShapiroGarry E Gold
Apr 15, 2008·Osteoarthritis and Cartilage·M E BowersB C Fleming
Apr 6, 2017·International Journal of Rheumatic Diseases·Tadashi YasudaHiroshi Yamamoto
Sep 1, 2007·The American Journal of Sports Medicine·L Stefan LohmanderEwa M Roos
Mar 29, 2014·Journal of Biomechanical Engineering·Yongnam SongNicholas J Giori
Oct 27, 2015·Journal of Biomechanical Engineering·Paul BriantThomas Andriacchi
Sep 22, 2018·Scientific Reports·Z AbusaraW Herzog
Oct 1, 2010·Topics in Magnetic Resonance Imaging : TMRI·Agnes G d'Entremont, David R Wilson
Jul 10, 2019·Journal of Magnetic Resonance Imaging : JMRI·Rajiv G MenonRavinder R Regatte
Nov 27, 2018·Biomechanics and Modeling in Mechanobiology·Yoonjin KimYongnam Song

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