Abstract
To prospectively assess clinical outcomes and regeneration of osteoarthritic cartilage lesions treated with an articular cartilage paste grafting technique. Prospective, longitudinal case series. We treated 125 patients (136 procedures; 34% female, 66% male; mean age, 46 years; range, 17 to 73 years) with an Outerbridge classification of grade IV lesions with an articular cartilage paste graft. Clinical data were recorded 2 to 12 years from surgery, with 20 of 145 patients lost to follow-up over 12 years (13.7%). Clinical outcomes were captured annually with validated Western Ontario and McMaster Universities Arthritis Index (WOMAC), International Knee Documentation Committee (IKDC), and Tegner subjective questionnaires. Regenerated cartilage biopsy specimens were obtained at second-look arthroscopy from 66 patients and evaluated as to quality and quantity of defect fill by a blinded, independent histopathology reviewer. Preoperative versus postoperative validated pain, functioning, and activity measures improved significantly (P< .001). Clinically, 18 of the 125 patients were considered failures (14.4%), with 10 patients undergoing subsequent joint arthroplasty and 8 who reported worse pain after surgery. Regional histologic v...Continue Reading
References
Apr 1, 1990·Calcified Tissue International·D RobinsonZ Nevo
Nov 1, 1990·The Journal of Bone and Joint Surgery. British Volume·G N HommingaA J van der Linden
Jan 1, 1990·The Journal of Bone and Joint Surgery. British Volume·D S Muckle, R J Minns
Jan 1, 1989·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D A GrandeM Klein
Jul 1, 1987·Clinical Orthopaedics and Related Research·S ItayZ Nevo
Jan 1, 1986·The Journal of Bone and Joint Surgery. British Volume·J E Aston, G Bentley
Apr 9, 1971·Nature·G Bentley, R B Greer
Nov 1, 1984·The Journal of Hand Surgery·H SeradgeE Atasoy
Jul 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·F GuilakV C Mow
Jul 1, 1994·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D A HendricksonG Lust
Sep 1, 1994·The Journal of Bone and Joint Surgery. American Volume·J A Buckwalter, S Lohmander
Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson
Jan 1, 1996·The Journal of Bone and Joint Surgery. American Volume·H J Mankin, J A Buckwalter
Jan 1, 1996·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·V Bobić
Jun 1, 1996·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·C J Wirth, M Rudert
Jul 1, 1997·Journal of Anatomy·C A Poole
Apr 21, 1998·The American Journal of Sports Medicine·A P Newman
Feb 7, 2003·The Journal of Bone and Joint Surgery. American Volume·U HorasR Schnettler
Apr 8, 2003·The Journal of Bone and Joint Surgery. British Volume·G BentleyJ Pringle
Nov 1, 1961·The Journal of Bone and Joint Surgery. British Volume·R E OUTERBRIDGE
Mar 5, 2004·The Journal of Bone and Joint Surgery. American Volume·Gunnar KnutsenOddmund Johansen
Feb 11, 2005·The American Journal of Sports Medicine·J Winslow Alford, Brian J Cole
Sep 6, 2005·The Journal of Bone and Joint Surgery. American Volume·Kai MithoeferRobert G Marx
Citations
Feb 22, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·A MarmottiG M Peretti
May 11, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Linzi XingYan Xu
Dec 25, 2012·Rheumatology International·E Carlos Rodriguez-Merchan
Feb 5, 2013·Current Reviews in Musculoskeletal Medicine·Brandon J EricksonBrian J Cole
Jul 2, 2009·Nature Reviews. Rheumatology·Farida DjouadChristian Jorgensen
Dec 3, 2014·The Knee·Kevin R StoneThomas J Turek
Oct 31, 2008·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Kevin R Stone
Dec 4, 2015·Scientific Reports·Qingyang MengYingfang Ao
Oct 4, 2016·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Kevin R StoneThomas J Turek
Jan 6, 2012·The Journal of Bone and Joint Surgery. American Volume·Elizaveta KonSandro Giannini
Jun 14, 2013·The American Journal of Sports Medicine·Giuseppe FilardoMaurilio Marcacci
Jul 16, 2015·Cartilage·Bjørn Borsøe ChristensenMartin Lind
Jan 24, 2014·Acta ortopedica brasileira·Márcio de Oliveira CarneiroJosé Barbieri Neto
Dec 17, 2014·HNO·M Kovacevic, J Wurm
May 13, 2020·Cartilage·Daniel GrandeKevin R Stone
Jul 3, 2010·The Journal of Bone and Joint Surgery. British Volume·K R StoneT J Turek
Jul 1, 2010·Cartilage·Timothy R McAdamsBert R Mandelbaum
Oct 1, 2011·Cartilage·Jack Farr, Jian Q Yao
Nov 8, 2017·Foot & Ankle International·Bryan Van DykeTerrence M Philbin
Jul 28, 2020·Cartilage·Gian M SalzmannBrian J Cole
Sep 23, 2020·International Orthopaedics·Alessandro Di MartinoGiuseppe Filardo