Articular cartilage paste grafting to full-thickness articular cartilage knee joint lesions: a 2- to 12-year follow-up

Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Kevin R StoneDonald P Speer

Abstract

To prospectively assess clinical outcomes and regeneration of osteoarthritic cartilage lesions treated with an articular cartilage paste grafting technique. Prospective, longitudinal case series. We treated 125 patients (136 procedures; 34% female, 66% male; mean age, 46 years; range, 17 to 73 years) with an Outerbridge classification of grade IV lesions with an articular cartilage paste graft. Clinical data were recorded 2 to 12 years from surgery, with 20 of 145 patients lost to follow-up over 12 years (13.7%). Clinical outcomes were captured annually with validated Western Ontario and McMaster Universities Arthritis Index (WOMAC), International Knee Documentation Committee (IKDC), and Tegner subjective questionnaires. Regenerated cartilage biopsy specimens were obtained at second-look arthroscopy from 66 patients and evaluated as to quality and quantity of defect fill by a blinded, independent histopathology reviewer. Preoperative versus postoperative validated pain, functioning, and activity measures improved significantly (P< .001). Clinically, 18 of the 125 patients were considered failures (14.4%), with 10 patients undergoing subsequent joint arthroplasty and 8 who reported worse pain after surgery. Regional histologic v...Continue Reading

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Citations

Feb 22, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·A MarmottiG M Peretti
May 11, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Linzi XingYan Xu
Dec 25, 2012·Rheumatology International·E Carlos Rodriguez-Merchan
Feb 5, 2013·Current Reviews in Musculoskeletal Medicine·Brandon J EricksonBrian J Cole
Jul 2, 2009·Nature Reviews. Rheumatology·Farida DjouadChristian Jorgensen
Dec 3, 2014·The Knee·Kevin R StoneThomas J Turek
Oct 31, 2008·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Kevin R Stone
Oct 4, 2016·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Kevin R StoneThomas J Turek
Jan 6, 2012·The Journal of Bone and Joint Surgery. American Volume·Elizaveta KonSandro Giannini
Jan 24, 2014·Acta ortopedica brasileira·Márcio de Oliveira CarneiroJosé Barbieri Neto
Dec 17, 2014·HNO·M Kovacevic, J Wurm
Jul 1, 2010·Cartilage·Timothy R McAdamsBert R Mandelbaum

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