PMID: 9524520Apr 3, 1998Paper

Articular cartilage repair. Rabbit experiments with a collagen gel-biomatrix and chondrocytes cultured in it

Acta Orthopaedica Scandinavica
S KawamuraT Ochi

Abstract

To repair a full-thickness articular cartilage defect in rabbit knees, we developed a technique of using a collagen gel hardened by cultured allogeneic chondrocytes in it. The gel-chondrocyte composite accumulated an intense metachromatic matrix, and had elasticity and stiffness enough to be shaped easily after 2 weeks' culture in vitro. It was implanted into full-thickness articular cartilage defects. Histologic evaluation was performed up to 6 months after surgery, using a histologic grading scale composed of 5 categories. In the gel-chondrocyte composite implanted group, good repair was observed from as early as 1 day up to 6 months. On the other hand, in the empty control group, no repair was observed 1 day to 2 weeks after the defects were made. At 4 weeks, some repair occurred, but even at 6 months the repair was not good.

References

Jan 1, 1989·The Journal of Bone and Joint Surgery. British Volume·S WakitaniK Ono
Jan 1, 1989·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D A GrandeM Klein
Jan 1, 1986·The Journal of Bone and Joint Surgery. British Volume·J E Aston, G Bentley
Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson
Apr 1, 1994·The Journal of Bone and Joint Surgery. American Volume·S WakitaniV M Goldberg

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Citations

Aug 22, 2000·Journal of Biomedical Materials Research·M S PonticielloF P Barry
Nov 15, 2000·Journal of Biomedical Materials Research·S PelletierE Dellacherie
Oct 2, 2002·Arthritis and Rheumatism·Dirk SchaeferLisa E Freed
May 10, 2002·Biotechnology and Bioengineering·Erik F PetersenEric W McFarland
May 10, 2002·Journal of Biomedical Materials Research·Tun AungNorio Ohshima
Feb 6, 2004·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Mei Wang, Changlong Yu
Dec 7, 2005·Archives of Orthopaedic and Trauma Surgery·A LahmD Maier
Feb 28, 2008·Journal of Bone and Mineral Metabolism·Shigeyuki WakitaniKunio Takaoka
Mar 29, 2005·Biomaterials·Gamze Torun KöseVasif Hasirci
Oct 18, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kanda ChaipinyoMarie-Paule I van Damme
Oct 20, 2005·Journal of Bioscience and Bioengineering·Mutsumi TakagiToshiomi Yoshida
Mar 23, 2011·Chemical Reviews·Biji Balakrishnan, R Banerjee
Dec 20, 2008·Journal de la Société de biologie·Marie-Thérèse CorvolFrançois Rannou
Jul 22, 2004·Tissue Engineering·Christopher J Hunter, Marc E Levenston
Jan 1, 2009·Tissue Engineering. Part a·Zhen LiMartin J Stoddart
Oct 17, 2009·Tissue Engineering. Part B, Reviews·Constance R ChuStephen Bruno
Jun 16, 2011·Croatian Medical Journal·Henning Madry, Magali Cucchiarini
Sep 29, 2015·Tissue Engineering. Part B, Reviews·Gun-Il Im
May 14, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Rani RoyLawrence J Bonassar
Aug 31, 2006·Journal of Biomedical Materials Research. Part a·Yi HongJiacong Shen
Apr 26, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Eva FilováEvzen Amler
May 19, 2004·Biochemical and Biophysical Research Communications·T T ChowdhuryD A Lee
Jul 6, 2000·The Orthopedic Clinics of North America·W J O'ConnorJ M Lane
Mar 20, 2012·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Yusuke MoritaShigehiko Suzuki

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