Articular cartilage vesicles and calcium crystal deposition diseases

Current Opinion in Rheumatology
A K Rosenthal

Abstract

Articular cartilage vesicles (ACVs) are small extracellular vesicles that serve as foci of pathologic calcium crystal deposition in articular cartilage matrix. In this review, I have summarized the role of ACVs in calcium crystal formation and discuss recent findings that impact our understanding of the content, behavior, and origin of ACVs in healthy and diseased joints. The burgeoning interest in extracellular vesicles in other fields renders this a timely and relevant topic. I have highlighted recent studies demonstrating that some ACVs originate in the autophagic pathway in healthy articular chondrocytes. I have reviewed accumulating evidence that nonmineralizing functions of ACVs contribute to osteoarthritis. I have also discussed new work supporting a role for extracellular vesicles in interleukin-1β-induced mineralization and in mediating the catabolic effects of synovial inflammation in osteoarthritis. We are making slow and steady progress in understanding the origin and function of ACVs and other relevant extracellular vesicles in arthritis. Further work in this interesting area is warranted.

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Citations

Dec 13, 2016·Current Opinion in Rheumatology·Alyssa K CarlsonRonald K June
Oct 17, 2017·Current Opinion in Rheumatology·Shigeru Miyaki, Martin K Lotz
Mar 25, 2020·Biological Reviews of the Cambridge Philosophical Society·Jian-Fei YanKai Jiao
Sep 10, 2020·Frontiers in Immunology·Yupeng HuangQibing Xie
Nov 8, 2017·Biochimica Et Biophysica Acta. General Subjects·Massimo BottiniRene Buchet
Jul 6, 2021·Journal of Neuroimmunology·Rasoul MirzaeiSajad Karampoor

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Methods Mentioned

BETA
electron microscopy

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