Artifacts in Fourier transform mass spectrometry.

Rapid Communications in Mass Spectrometry : RCM
Raman Mathur, Peter B O'Connor

Abstract

Recent work on a new, higher sensitivity preamplifier design for Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS) revealed a number of artifact peaks (spectral features) which do not contain useful chemical information. In order to determine the cause of these artifacts and eliminate them, these severely distorted spectra were compared with similarly distorted signal models. The source of several common signal processing artifacts was thereby determined and correlated to radio-frequency interference (RFI) noise and saturation of the amplifier and/or the digitizer. Under such conditions, the fast Fourier transform (FFT) generates spectral artifact peaks corresponding to harmonics and mixing frequencies of the real signal peaks and RFI frequencies. While this study was done using FTICRMS data, it is important to stress that these artifacts are inherent to the digitization and FFT process and thus are relevant to any FT-based MS instrument, including the orbitrap and FT ion trap.

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Citations

Apr 10, 2013·Journal of the American Society for Mass Spectrometry·Yulin QiPeter B O'Connor
Jul 1, 2009·Bioanalysis·Michaela Scigelova, Alexander Makarov
Sep 28, 2014·Journal of the American Society for Mass Spectrometry·Alan L Rockwood, John C L Erve
Oct 23, 2014·Journal of Proteome Research·Navin Rauniyar, John R Yates
Sep 8, 2012·Rapid Communications in Mass Spectrometry : RCM·Piotr T KasperRob J Vreeken
Apr 3, 2012·Rapid Communications in Mass Spectrometry : RCM·A Kaufmann, S Walker
Aug 1, 2012·Rapid Communications in Mass Spectrometry : RCM·Yulin QiPeter B O'Connor
Apr 14, 2012·Rapid Communications in Mass Spectrometry : RCM·Ilaria SognoAdriana Albini
Jan 10, 2014·Mass Spectrometry Reviews·Yulin Qi, Peter B O'Connor
Jul 28, 2015·Trends in Analytical Chemistry : TRAC·Arpana Vaniya, Oliver Fiehn
Sep 23, 2020·European Journal of Mass Spectrometry·Edgar White Buenger, Gavin E Reid
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Joshua M MitchellHunter N B Moseley
Feb 14, 2019·Journal of the American Society for Mass Spectrometry·Joshua T JohnsonScott A McLuckey

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