Artifacts produced by using dichloromethane in the extraction and storage of some antihistaminic drugs

Journal of Chromatography
A H Beckett, H M Ali

Abstract

The use of dichloromethane for the extraction of amines may lead to the formation of artifacts. Dichloromethane reacts rapidly (37.5 degrees) with brompheniramine, diphenylpyraline, cyclizine, cyproheptadine but not with antazoline and lignocaine. This difference in reactivity as well as the thin-layer chromatographic, gas-liquid chromatographic, nuclear magnetic resonance, and mass spectrometric characteristics of cyclizine and diphenylpyraline chloromethochlorides are investigated.

References

Feb 1, 2003·Journal of Pharmaceutical and Biomedical Analysis·Min LiDiana M Watkins
Nov 3, 2012·Journal of Analytical Toxicology·Fessessework GualeAshraf Mozayani
Oct 23, 2014·International Journal of Critical Illness and Injury Science·Ashish Bhalla

Citations

Jan 1, 1974·Zeitschrift für Rechtsmedizin. Journal of legal medicine·M BlomquistR Ryhage

Related Concepts

Hydrocarbons, Chlorinated
In Vivo NMR Spectroscopy
Amines
Magnetic Resonance Imaging
Cyclizine
Mass Spectrometry
Solaesthin
Diphenylpyraline
Antihistamines, Classical
Lidocaine

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