PMID: 6395808Jan 1, 1984

Artificial cells in medicine and biotechnology

Applied Biochemistry and Biotechnology
T M Chang


Since the feasibility of artificial cells was first demonstrated in 1957 [Chang (1, 2)], an increasing number of approaches to their preparation and use have become available. Thus artificial cell membranes can now be formed using a variety of synthetic or biological materials to produce desired variations in their permeability, surface properties, and blood compatibility. Almost any material can be included within artificial cells. These include enzyme systems, cell extracts, biological cells, magnetic materials, isotopes, antigens, antibodies, vaccines, hormones, adsorbents, and others. Since cells are the fundamental units of living organisms, it is not surprising that artificial cells can have a number of possible applications. This is especially so since artificial cells can be "tailor-made" to have very specialized functions. A number of potential applications suggested earlier have now reached a developmental stage appropriate for clinical trial or application. These clinical applications include the use of such cells as a red blood cell substitute, in hemoperfusion, in an artificial kidney or artificial liver, as detoxifiers, in an artificial pancreas, and so on. Artificial red blood cells based on lipid-coated fluoroca...Continue Reading


Jun 1, 1979·Biulleten' eksperimental'noĭ biologii i meditsiny·V G Zin'kovskiĭS A Andronati
Mar 22, 1976·Biochemical and Biophysical Research Communications·J Campbell, T M Chang
Jan 1, 1977·Transactions - American Society for Artificial Internal Organs·M C GelfandG E Schreiner
Nov 7, 1977·Biochemical and Biophysical Research Communications·J Cousineau, T M Chang
Jun 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S C TamJ T Wong
Jan 4, 1975·British Medical Journal·J A ValeR Goulding
Mar 11, 1976·Biochimica Et Biophysica Acta·H L SchmidtG Grenner
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·G M IhlerF W Schnure
Oct 10, 1973·Biochimica Et Biophysica Acta·T MoriI Chibata
Jan 1, 1972·Transactions - American Society for Artificial Internal Organs·R E SparksO Lindan
Jan 1, 1972·Transactions - American Society for Artificial Internal Organs·T M ChangT Lee-Burns
May 1, 1973·Biotechnology and Bioengineering·J C Ostergaard, S C Martiny
Apr 1, 1974·Canadian Journal of Physiology and Pharmacology·T M Chang
Jun 9, 1972·Biochemical and Biophysical Research Communications·S W May, N N Li
Dec 1, 1969·Canadian Journal of Physiology and Pharmacology·T M Chang
Feb 1, 1968·Journal of Theoretical Biology·P Mueller, D O Rudin
Jun 1, 1968·Journal of Biomedical Materials Research·T M Chang, M J Poznansky
Jan 1, 1966·Canadian Journal of Physiology and Pharmacology·T M ChangS G Mason
Jul 1, 1967·Canadian Journal of Physiology and Pharmacology·T M ChangO J Ransome
Nov 4, 1967·Nature·H A Sloviter, T Kamimoto
Sep 25, 1982·Lancet·A E GimsonR Williams
Jan 1, 1984·Applied Biochemistry and Biotechnology·P Speiser
Jan 1, 1984·Applied Biochemistry and Biotechnology·F ErganT M Chang
Jun 1, 1982·Bulletin of Environmental Contamination and Toxicology·A L Smrek, L L Needham
Jan 15, 1981·The New England Journal of Medicine·W I BensingerE D Thomas
Apr 1, 1971·FEBS Letters·G GregoriadisB E. Ryman
Oct 23, 1964·Science·T M Chang


Mar 5, 1996·Biotechnology and Bioengineering·K D GreenE N Vulfson
Jan 1, 1987·Pharmacology & Therapeutics·V Bocci
May 4, 2013·Nature Protocols·Sebastian LeptihnMark I Wallace
Jun 1, 1988·Artificial Organs·T M ChangG Reach
Nov 11, 1988·Science·J S Hanker, B L Giammara
Jan 1, 1994·Journal of Microencapsulation·D PonceletR J Neufeld
Sep 21, 2006·Journal of Biotechnology·Georgia A Kotzia, Nikolaos E Labrou
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·V Dixit, G Gitnick
Nov 21, 2007·Journal of Liposome Research·Hiromi Sakai, Eishun Tsuchida
Jan 1, 1987·Biomaterials, Artificial Cells, and Artificial Organs·T M Chang
Jul 1, 1988·Journal of Biomaterials Applications·T M Chang
May 19, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Huibin YuShenqi Wang
Jan 1, 1995·Journal of Biomaterials Science. Polymer Edition·V Dixit, G Gitnick
Dec 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V DixitG Gitnick
Jan 1, 1992·Applied Biochemistry and Biotechnology·M Monshipouri, R J Neufeld
Apr 8, 2010·Biochemistry. Biokhimii︠a︡·S BansalB Kundu
Jan 1, 1984·International Urology and Nephrology·S I RyabovA B Scherbitsky
Jan 1, 1988·Veterinary Research Communications·J E Van DijkC Holzhauer
Feb 13, 1999·Paediatric and Perinatal Epidemiology·S R SaldivaE Massad
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·V Dixit
Jan 1, 1992·Critical Reviews in Food Science and Nutrition·E S Tee
Jan 1, 1992·Cell Transplantation·M L YarmushR G Tompkins

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