PMID: 6395808Jan 1, 1984

Artificial cells in medicine and biotechnology

Applied Biochemistry and Biotechnology
T M Chang

Abstract

Since the feasibility of artificial cells was first demonstrated in 1957 [Chang (1, 2)], an increasing number of approaches to their preparation and use have become available. Thus artificial cell membranes can now be formed using a variety of synthetic or biological materials to produce desired variations in their permeability, surface properties, and blood compatibility. Almost any material can be included within artificial cells. These include enzyme systems, cell extracts, biological cells, magnetic materials, isotopes, antigens, antibodies, vaccines, hormones, adsorbents, and others. Since cells are the fundamental units of living organisms, it is not surprising that artificial cells can have a number of possible applications. This is especially so since artificial cells can be "tailor-made" to have very specialized functions. A number of potential applications suggested earlier have now reached a developmental stage appropriate for clinical trial or application. These clinical applications include the use of such cells as a red blood cell substitute, in hemoperfusion, in an artificial kidney or artificial liver, as detoxifiers, in an artificial pancreas, and so on. Artificial red blood cells based on lipid-coated fluoroca...Continue Reading

References

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Citations

Mar 5, 1996·Biotechnology and Bioengineering·K D GreenE N Vulfson
Jan 1, 1987·Pharmacology & Therapeutics·V Bocci
May 4, 2013·Nature Protocols·Sebastian LeptihnMark I Wallace
Jun 1, 1988·Artificial Organs·T M ChangG Reach
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Related Concepts

Metazoa
Artificial Organs
Artificial Erythrocytes
Microcapsules Drug Delivery System
Immunosorbents
Renal Dialysis Machine
Liver
Study of Magnetics
Membranes, Artificial
Poisoning

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