Artificial Channels in an Infectious Biofilm Created by Magnetic Nanoparticles Enhanced Bacterial Killing by Antibiotics

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Kecheng QuanHenk J Busscher

Abstract

The poor penetrability of many biofilms contributes to the recalcitrance of infectious biofilms to antimicrobial treatment. Here, a new application for the use of magnetic nanoparticles in nanomedicine to create artificial channels in infectious biofilms to enhance antimicrobial penetration and bacterial killing is proposed. Staphylococcus aureus biofilms are exposed to magnetic-iron-oxide nanoparticles (MIONPs), while magnetically forcing MIONP movement through the biofilm. Confocal laser scanning microscopy demonstrates artificial channel digging perpendicular to the substratum surface. Artificial channel digging significantly (4-6-fold) enhances biofilm penetration and bacterial killing efficacy by gentamicin in two S. aureus strains with and without the ability to produce extracellular polymeric substances. Herewith, this work provides a simple, new, and easy way to enhance the eradication of infectious biofilms using MIONPs combined with clinically applied antibiotic therapies.

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Citations

Oct 1, 2020·Biomaterials Science·Shuting WangJian Ji
May 7, 2020·Nature Communications·Huan GuDacheng Ren
May 23, 2020·Advanced Science·Samuel CheesemanAaron Elbourne
Jun 13, 2020·Frontiers in Microbiology·Rita M PintoPatrick Van Dijck
Jan 5, 2021·Critical Reviews in Food Science and Nutrition·Dan LiuXin-An Zeng
Aug 20, 2021·Critical Reviews in Microbiology·Kecheng QuanHenny C van der Mei
Sep 25, 2021·Advanced Science·Mohammad J HajipourMorteza Mahmoudi

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