Artificial insemination and in-vitro fertilization using donor spermatozoa: a report on 15 years of experience

Human Reproduction
G N ClarkeH W Baker

Abstract

Donor insemination (DI) using cryopreserved semen commenced at The Royal Women's Hospital in 1976. Over the next 15 years we performed 5953 treatment cycles to achieve 816 pregnancies (13.7% per cycle) and 706 live births. In-vitro fertilization (IVF) using donor spermatozoa commenced in 1986. Over the next 5 years we performed 303 treatment cycles for 185 couples. Including subsequent transfer of cryopreserved embryos, a total of 33% of couples achieved a successful pregnancy by IVF. Statistical analysis indicated that, for DI pregnancies, the most important semen variable was the percentage post-thaw motility, whilst for normal fertilization in IVF it was the pre-freeze motility. These results may be explained by the compensatory effects of post-thaw processing of spermatozoa for IVF, but not for DI in our clinic.

Citations

Aug 1, 1987·Journal of in Vitro Fertilization and Embryo Transfer : IVF·M Brumby, P Kasimba
Feb 3, 2009·Journal of Assisted Reproduction and Genetics·Jeff G WangMark V Sauer
Aug 24, 1999·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·B M Dickens, R J Cook
Oct 13, 2004·Journal of Andrology·Nathalie Mousset-SiméonBertrand Mace
Feb 27, 2004·Reproduction, Fertility, and Development·G N ClarkeH W G Baker
Oct 16, 2015·Reproduction, Fertility, and Development·Lara TamburrinoMonica Muratori

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