Artificial intelligence-based pathology for gastrointestinal and hepatobiliary cancers.

Gut
Julien Calderaro, Jakob Nikolas Kather

Abstract

Artificial intelligence (AI) can extract complex information from visual data. Histopathology images of gastrointestinal (GI) and liver cancer contain a very high amount of information which human observers can only partially make sense of. Complementing human observers, AI allows an in-depth analysis of digitised histological slides of GI and liver cancer and offers a wide range of clinically relevant applications. First, AI can automatically detect tumour tissue, easing the exponentially increasing workload on pathologists. In addition, and possibly exceeding pathologist's capacities, AI can capture prognostically relevant tissue features and thus predict clinical outcome across GI and liver cancer types. Finally, AI has demonstrated its capacity to infer molecular and genetic alterations of cancer tissues from histological digital slides. These are likely only the first of many AI applications that will have important clinical implications. Thus, pathologists and clinicians alike should be aware of the principles of AI-based pathology and its ability to solve clinically relevant problems, along with its limitations and biases.

References

Aug 18, 2005·British Journal of Cancer·A L Harris
Aug 18, 2005·British Journal of Cancer·L M McShaneUNKNOWN Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
Sep 2, 2010·Journal of Pathology Informatics·Bryan Dangott, Anil Parwani
Jun 9, 2012·Clinical Journal of the American Society of Nephrology : CJASN·John W Pickering, Zoltan H Endre
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Oct 27, 2012·Science Translational Medicine·Yinyin YuanFlorian Markowetz
Feb 13, 2015·Nature Reviews. Cancer·Henry T LynchMegan P Hitchins
Jun 2, 2015·The New England Journal of Medicine·Dung T LeLuis A Diaz
Jun 17, 2016·Scientific Reports·Jakob Nikolas KatherFrank Gerrit Zöllner
Oct 7, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kumardeep ChaudharyLana X Garmire
Dec 14, 2017·JAMA : the Journal of the American Medical Association·Babak Ehteshami BejnordiRui Venâncio
Dec 28, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marianne ZiolJulien Calderaro
Feb 23, 2018·Scientific Reports·Dmitrii BychkovJohan Lundin
Mar 5, 2018·Seminars in Cancer Biology·Jakob Nikolas KatherDirk Jaeger
Mar 14, 2018·Proceedings of the National Academy of Sciences of the United States of America·Pooya MobadersanyLee A D Cooper
May 20, 2018·Nature Reviews. Cancer·Ahmed HosnyHugo J W L Aerts
Jul 4, 2018·PLoS Biology·Claire McQuinAnne E Carpenter
Sep 14, 2018·Scientific Reports·Korsuk SirinukunwattanaNasir Rajpoot
Oct 12, 2018·Archives of Pathology & Laboratory Medicine·Mark D ZarellaDouglas J Hartman
Oct 13, 2018·The American Journal of Surgical Pathology·David F SteinerMartin C Stumpe
Dec 7, 2018·Journal of Clinical Pathology·Nina LinderClare Verrill
Jan 5, 2019·Journal of Pathology Informatics·Hamid Reza Tizhoosh, Liron Pantanowitz
Mar 3, 2019·Cellular Oncology (Dordrecht)·Oscar G F GeessinkJeroen A W M van der Laak
Apr 12, 2019·Frontiers in Bioengineering and Biotechnology·Mary ShapcottNasir Rajpoot
May 28, 2019·Nature Methods·Erick MoenDavid Van Valen
Jun 14, 2019·Journal of Hepatology·Julien CalderaroJessica Zucman-Rossi
Jul 6, 2019·Journal of the American Society of Cytopathology : JASC·Michael S Landau, Liron Pantanowitz
Jul 22, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Achim HeklerTitus J Brinker
Aug 11, 2019·Nature Reviews. Clinical Oncology·Kaustav BeraAnant Madabhushi
Aug 15, 2019·Cancer Cytopathology·Adit B SanghviLiron Pantanowitz
Oct 1, 2019·IEEE Journal of Biomedical and Health Informatics·Davood KarimiSeptimiu E Salcudean
Nov 5, 2019·Frontiers in Medicine·Yves-Rémi Van EyckeChristine Decaestecker
Nov 19, 2019·Frontiers in Bioengineering and Biotechnology·Justin Tyler PontalbaApril Khademi

❮ Previous
Next ❯

Citations

Jun 18, 2021·World Journal of Gastroenterology : WJG·Hiroshi Yoshida, Tomoharu Kiyuna
Jun 25, 2021·Hepatic Medicine : Evidence and Research·James Neuberger, Owen Cain

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved