Artificial intelligence for morphology-based function prediction in neovascular age-related macular degeneration

Scientific Reports
Leon von der EmdeSteffen Schmitz-Valckenberg

Abstract

Spatially-resolved mapping of rod- and cone-function may facilitate monitoring of macular diseases and serve as a functional outcome parameter. However, mesopic and dark-adapted two-color fundus-controlled perimetry (FCP, also called "microperimetry") constitute laborious examinations. We have devised a machine-learning-based approach to predict mesopic and dark-adapted (DA) retinal sensitivity in eyes with neovascular age-related macular degeneration (nAMD). Extensive psychophysical testing and volumetric multimodal retinal imaging data were acquired including mesopic, DA red and DA cyan FCP, spectral-domain optical coherence tomography and confocal scanning laser ophthalmoscopy infrared reflectance and fundus autofluorescence imaging. With patient-wise leave-one-out cross-validation, we have been able to achieve prediction accuracies of (mean absolute error, MAE [95% CI]) 3.94 dB [3.38, 4.5] for mesopic, 4.93 dB [4.59, 5.27] for DA cyan and 4.02 dB [3.63, 4.42] for DA red testing. Partial addition of patient-specific sensitivity data decreased the cross-validated MAE to 2.8 dB [2.51, 3.09], 3.71 dB [3.46, 3.96], and 2.85 dB [2.62, 3.08]. The most important predictive feature was outer nuclear layer thickness. This artificial ...Continue Reading

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Citations

Aug 29, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Maximilian PfauFrank G Holz
Apr 30, 2020·The British Journal of Ophthalmology·Maximilian PfauPhilipp L Müller
Aug 6, 2020·Journal of Clinical Medicine·Philipp L MüllerFrank G Holz
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Oct 7, 2020·Progress in Retinal and Eye Research·Maximilian PfauSteffen Schmitz-Valckenberg
Jan 16, 2021·Scientific Reports·Philipp L MüllerMaximilian Pfau
Mar 21, 2021·Survey of Ophthalmology·David Benet, Oscar J Pellicer-Valero
Mar 27, 2021·Eye·Leon von der EmdeSteffen Schmitz-Valckenberg
Mar 27, 2021·British Journal of Pharmacology·Chloe N ThomasLisa J Hill
Jun 25, 2021·Progress in Retinal and Eye Research·Ursula Schmidt-ErfurthHrvoje Bogunović
Jun 30, 2021·Translational Vision Science & Technology·Maximilian PfauJoelle A Hallak
Feb 11, 2021·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Yesa Yang, Hannah Dunbar

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Clinical Trials Mentioned

NCT02418754
NCT01944839
NCT01940900

Software Mentioned

ImageJ
R package lme4
R package forestFloor
Spectralis Viewing Module
R

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