Artificial light at night: melatonin as a mediator between the environment and epigenome

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Abraham Haim, Abed E Zubidat

Abstract

The adverse effects of excessive use of artificial light at night (ALAN) are becoming increasingly evident and associated with several health problems including cancer. Results of epidemiological studies revealed that the increase in breast cancer incidents co-distribute with ALAN worldwide. There is compiling evidence that suggests that melatonin suppression is linked to ALAN-induced cancer risks, but the specific genetic mechanism linking environmental exposure and the development of disease is not well known. Here we propose a possible genetic link between environmental exposure and tumorigenesis processes. We discuss evidence related to the relationship between epigenetic remodelling and oncogene expression. In breast cancer, enhanced global hypomethylation is expected in oncogenes, whereas in tumour suppressor genes local hypermethylation is recognized in the promoter CpG chains. A putative mechanism of action involving epigenetic modifications mediated by pineal melatonin is discussed in relation to cancer prevalence. Taking into account that ALAN-induced epigenetic modifications are reversible, early detection of cancer development is of great significance in the treatment of the disease. Therefore, new biomarkers for ci...Continue Reading

References

Feb 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R G StevensB W Wilson
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J Sved, A Bird
Jan 1, 1969·Neuroendocrinology·R J Reiter, F Fraschini
Jul 1, 1983·The Journal of the American Dental Association·G R Hartwell, P A Cecic
Jan 5, 1995·The New England Journal of Medicine·C A CzeislerJ F Rizzo
Mar 1, 1996·Environmental Health Perspectives·R G Stevens, S Davis
Apr 16, 1998·Environmental Health Perspectives·T M CrispY M Patel
Jul 29, 1999·British Journal of Cancer·P K VerkasaloS L Rudanko
Jul 27, 2001·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·W FischleE Verdin
Oct 18, 2001·Journal of the National Cancer Institute·S DavisR G Stevens
Nov 14, 2002·The Biochemical Journal·Annemieke J M de RuijterAndré B P van Kuilenburg
Dec 6, 2002·Journal of Biological Rhythms·E B KlermanC A Czeisler
Jun 6, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Russel J Reiter
Jun 28, 2003·Science·Satchidananda PandaJohn B Hogenesch
Dec 19, 2003·Chronobiology International·N Mrosovsky, S Hattar
May 18, 2004·Genes & Development·Gunnar SchottaThomas Jenuwein
Jun 3, 2004·Journal of Psychosomatic Research·Maurice M Ohayon
Aug 18, 2004·Biochemical Pharmacology·Moshe SzyfShafaat A Rabbani
Dec 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Christian CajochenAnna Wirz-Justice
Jan 29, 2005·Molecular Endocrinology·Peter Cheung, Priscilla Lau
Jun 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jennifer D CookCheryl Lyn Walker
Aug 4, 2005·Journal of Biological Rhythms·Josephine Arendt
Oct 4, 2005·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Leo Peichl
Dec 17, 2005·Epidemiology·Eva S SchernhammerSusan E Hankinson
Apr 6, 2006·Cancer Causes & Control : CCC·John D BulloughMariana G Figueiro
May 2, 2006·Cancer Detection and Prevention·Samuel CosEmilio J Sánchez-Barceló
Aug 21, 2007·Expert Review of Proteomics·Michael S Cosgrove
Nov 1, 2007·Dialogues in Clinical Neuroscience·Steven W LockleyDebra J Skene
Jan 16, 2008·Die Naturwissenschaften·Thomas C ErrenClaus Piekarski
Jul 2, 2008·Breast Cancer Research and Treatment·Ahmet KorkmazRussel J Reiter
May 12, 2009·Seminars in Cancer Biology·Amy M DworkinAmanda Ewart Toland
Jan 16, 2010·Trends in Endocrinology and Metabolism : TEM·Michael K SkinnerCarlos Guerrero-Bosagna
May 14, 2010·Science Translational Medicine·Joshua J GooleySteven W Lockley
Aug 4, 2010·Journal of Biological Rhythms·Sean W CainJeanne F Duffy
Aug 4, 2010·Cancer Causes & Control : CCC·Itai KloogBoris A Portnov
Nov 30, 2010·The Journal of Experimental Biology·Abed E ZubidatAbraham Haim
Dec 18, 2010·Journal of Applied Physiology·Kathleen E WestGeorge C Brainard

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Citations

May 1, 2015·Chronobiology International·Abraham Haim, Abed E Zubidat
Jan 23, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·N A RybnikovaB A Portnov
Apr 1, 2016·Archives of Environmental & Occupational Health·Nataliya A RybnikovaBoris A Portnov
May 26, 2015·European Journal of Pharmacology·Diego A GolombekDaniel P Cardinali
Mar 18, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kevin J GastonFranz Hölker
May 20, 2016·International Journal of Biometeorology·Katharina M A GabrielFranz Hölker
Apr 12, 2016·Journal of Pineal Research·Agorastos Agorastos, Astrid C E Linthorst
Dec 4, 2015·Integrative Cancer Therapies·Atalya Keshet-SittonAbraham Haim
Jul 7, 2017·Journal of Basic and Clinical Physiology and Pharmacology·Abed E Zubidat, Abraham Haim
May 17, 2018·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Valentina J AlaasamJenny Q Ouyang
Sep 9, 2017·Environmental Health Perspectives·Peter JamesFrancine Laden
Sep 16, 2018·The European Journal of Neuroscience·S K Tahajjul TaufiqueVinod Kumar
Feb 7, 2020·European Journal of Epidemiology·Jennifer RitonjaKristan J Aronson
Mar 7, 2020·Cells·Enrico MorettiRita Rezzani
Jul 17, 2018·Frontiers in Physiology·Marcelo TapiaClaus Behn
May 10, 2017·The Astrophysical Journal·A L MelottA C Overholt
Oct 6, 2020·Frontiers in Endocrinology·Zeeshan Ahmad KhanAsamanja Chattoraj
Apr 25, 2018·Chronobiology International·Palma-Gómez MadahiEscobar Carolina
Feb 19, 2020·Translational Psychiatry·William H WalkerRandy J Nelson
Sep 7, 2018·BioMed Research International·Hans G RichterClaudia Torres-Farfan
Jun 28, 2019·Frontiers in Endocrinology·Natalia MendezHans G Richter
Jul 28, 2019·Scientific Reports·Ünsal Veli ÜstündağEbru Emekli-Alturfan
Sep 10, 2020·Heliyon·D HerdiwijayaY Yulianti
Mar 9, 2021·Cellular and Molecular Life Sciences : CMLS·Leonardo Vinícius Monteiro de Assis, Henrik Oster
May 28, 2019·Psychoneuroendocrinology·Jeffrey GassenSarah E Hill
May 1, 2021·Diseases·Alejandro RomeroAntonio Juberias
Jul 3, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tânia AlbuquerqueDiana Costa

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