Artificial liver. State of the art

Digestive Diseases and Sciences
T TakahashiY Nosé

Abstract

If an effective hepatic assist system existed, it could serve as a bridge to transplantation. Most of the patients waiting for liver transplantation have chronic liver insufficiency but are not in hepatic coma. Various hepatic assist systems have been used to salvage patients with acute liver insufficiency. Most attempts have been disappointing. The methods used have included plasma exchange, plasma adsorption, double filtration, cryofiltration, thermofiltration, the combination of plasma exchange and amino acid hemodialysis, and others. For patients with chronic liver disease with moderate liver function impairment and limited to one or only a few areas of metabolic abnormality, a hepatic assist might allow the life of the patient to be maintained temporarily. The application of hepatic assist methods for chronic liver disease patients treated at the Cleveland Clinic has been encouraging. One of the patients who suffered from sclerosing cholangitis has maintained a near-normal life for almost five years by 170 plasma treatments. This is in spite of the fact that, at the onset of treatment, the patient was nearly comatose. Unfortunately, this patient did not wish to receive a liver transplantation. Based upon this experience, t...Continue Reading

References

Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M W ParizaV R Potter
Aug 21, 1976·Lancet·A J Knell, D C Dukes
Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·M W ParizaV R Potter
Jan 1, 1986·International Journal of Immunopharmacology·R J SmithS C Speziale
Feb 1, 1989·Transfusion·D M SuttonG Rock
May 1, 1986·Seminars in Liver Disease·R D Hughes, R Williams
Aug 1, 1988·Artificial Organs·N Inoue
Aug 1, 1988·Artificial Organs·P S MalcheskyY Nosé
Jan 1, 1988·Journal of Clinical Apheresis·P S MalcheskyY Nosé
Feb 1, 1988·Mayo Clinic Proceedings·S C Pappas
Feb 1, 1988·Alcoholism, Clinical and Experimental Research·J E BlakeH Orrego
Oct 1, 1986·Artificial Organs·M Matsushita, Y Nosé
Jun 1, 1986·Artificial Organs·M Mito
Nov 1, 1985·Artificial Organs·Y NoséJ W Smith
Jul 1, 1973·American Journal of Surgery·T SoyerB Eiseman
Sep 1, 1965·Annals of Surgery·B EisemanF Raffucci
Apr 2, 1982·Molecular and Cellular Biochemistry·A IchiharaK Tanaka
Sep 25, 1982·Lancet·A E GimsonR Williams
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Aug 16, 1984·Biochemical and Biophysical Research Communications·T NakamuraA Ichihara
Jan 1, 1983·Molecular and Cellular Biochemistry·C Guguen-Guillouzo, A Guillouzo
Jan 1, 1983·Cleveland Clinic Quarterly·P S MalcheskyY Nosé
Jan 1, 1980·Annals of the New York Academy of Sciences·A IchiharaH Shinno
Apr 1, 1982·Gastroenterologia Japonica·A E GimsonR Williams
Aug 1, 1980·Artificial Organs·P S MalcheskyY Nosé
Mar 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·J E KILEYC S WELCH

Citations

Sep 12, 2000·Current Gastroenterology Reports·P Rosenthal
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·J Michael Millis, Julian E Losanoff
May 18, 2000·Artificial Organs·Toru MizuguchiK Hirata
May 5, 2005·Tissue Engineering·Shinichi SugimotoToshihiro Mitaka
Aug 14, 2001·Journal of Clinical Gastroenterology·R Q Gill, R K Sterling
Oct 2, 2009·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·R LadurnerA Königsrainer
Mar 25, 1994·Biotechnology and Bioengineering·J RozgaT Giorgio
Jun 2, 2001·Clinics in Liver Disease·A SechserR W Osorio
Oct 28, 1998·Artificial Organs·A D SmirthwaiteM H Grant
Aug 23, 2002·The British Journal of Surgery·F G CourtGuy J Maddern
Jan 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H HoofnagleN Ascher
Jul 23, 1999·Annals of the New York Academy of Sciences·B Busse, J C Gerlach
Sep 6, 2003·ANZ Journal of Surgery·Fiona G CourtGuy J Maddern
Nov 29, 2002·The International Journal of Artificial Organs·M BorraG Bellini
Mar 1, 1995·Scandinavian Journal of Gastroenterology·X Wang, R Andersson
Jan 1, 1992·Cell Transplantation·M L YarmushR G Tompkins
Jul 18, 2003·The International Journal of Artificial Organs·Y QianY Shuhong

Related Concepts

Metazoa
Artificial Organs
Hemoperfusion
Liver
Liver Dysfunction
Plasma Exchange
Transplantation of Liver
History,20th Century

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