Artificial liver support at present and in the future.

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs
Kazuhiko OnoderaAkio Kawamura

Abstract

Liver failure is a fatal disease. Liver transplantation is the only established treatment for liver failure; however, donor shortages remain problematic. In the United States and Europe, artificial livers as a bridge to liver transplantation are being considered. In Japan, we have taken a different approach to the treatment of end-stage liver diseases because of the characteristics of the health-care insurance system, regulated by the government. Furthermore, cadaveric liver transplantations are unsuited to the social mores of Japanese culture. Practically speaking, we believe that plasma exchange (PE) and continuous hemodiafiltration (CHDF) are the most effective therapies for the treatment of liver failure, although randomized controlled studies are needed to determine their effects. Overall, we believe that the first line of treatment for liver failure should be PE and CHDF, and the second line should be bioartificial liver support. In the near future, we hope that both gene therapy and regenerative medicine will contribute to the development of a functional artificial liver.

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Citations

Nov 28, 2008·Biotechnology Letters·Xue-Hui ChuYi-Tao Ding
Nov 26, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Fumihiko MiuraTomoaki Eguchi
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Jun 8, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Tarek M EzzatSteven W M Olde Damink
Jun 19, 2007·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Y SawaH Watanabe
Dec 8, 2010·British Journal of Hospital Medicine·Clare OrmerodSimon Lal
Jun 7, 2021·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Kenji YoshinoJavier Briceño-Delgado
Jul 30, 2021·Current Opinion in Organ Transplantation·Asish C Misra, Devin Eckhoff

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